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Ovotesticular Disorder of Sex Development in Korean Children: A Single-Center Analysis over a 30-Year Period

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dc.contributor.author김혜인-
dc.contributor.author윤보현-
dc.contributor.author이용승-
dc.contributor.author이인하-
dc.contributor.author한상원-
dc.date.accessioned2021-10-21T00:07:27Z-
dc.date.available2021-10-21T00:07:27Z-
dc.date.issued2021-10-
dc.identifier.issn1083-3188-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/185387-
dc.description.abstractStudy objective: To present clinical features that characterize ovotesticular disorder of sex development (OT-DSD) in the Korean population. Among the patient cohort who were initially suspected to have OT-DSD, the actual OT-DSD patients and those of other disorder of sex development were compared. Design: Retrospective medical chart review of patients who were initially suspected to have OT-DSD from 1984 to 2018 on the basis of clinical examination. Setting: Tertiary care university hospital. Participants: Of 26 patients with initial diagnosis of OT-DSD, 3 were excluded because of incomplete records, and finally, 23 patients were subjected to analysis. Various examinations were performed before the surgical confirmation of gonad histopathology. Interventions: Medical records were reviewed for clinical, anatomical, biochemical, and cytogenic characteristics, gender assignment, medical treatment, and histopathologic diagnosis. Main outcome measures: Characteristics of OT-DSD in a Korean population. Results: Among 23 patients suspected to have OT-DSD, 13/23 (56.5%) were diagnosed as OT-DSD after histopathologic confirmation. Of the remaining 10 patients, 5/23 (21.7%) were diagnosed with mixed gonadal dysgenesis, 3 with Turner variant, 1 with 46,XX disorder of sex development, and 1 with Mayer-Rokitansky-Küster-Hauser syndrome. Among the 13 OT-DSD cases, 9 patients presented with the 46,XX karyotype, 1 with the 46,XY, and 3 with the 46,XX/XY karyotype. Nine patients were assigned as male and 4 as female at birth. The most common gonad histology was ovotestis 10/26 (38%), followed by ovary and testis. Conclusion: OT-DSD is one of the rarest disorders with various clinical presentations. A patient with ambiguous genitalia must be examined with a multidisciplinary approach with clinical suspicion for OT-DSD. Standardized procedure of evaluation and treatment is crucial.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Science-
dc.relation.isPartOfJOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleOvotesticular Disorder of Sex Development in Korean Children: A Single-Center Analysis over a 30-Year Period-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Obstetrics and Gynecology (산부인과학교실)-
dc.contributor.googleauthorHye In Kim-
dc.contributor.googleauthorInha Lee-
dc.contributor.googleauthorSang Hwa Kim-
dc.contributor.googleauthorYong Seung Lee-
dc.contributor.googleauthorSang Won Han-
dc.contributor.googleauthorBo Hyon Yun-
dc.identifier.doi10.1016/j.jpag.2021.02.105-
dc.contributor.localIdA05969-
dc.contributor.localIdA02555-
dc.contributor.localIdA02980-
dc.contributor.localIdA05497-
dc.contributor.localIdA04285-
dc.relation.journalcodeJ04118-
dc.identifier.eissn1873-4332-
dc.identifier.pmid33667640-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1083318821001492-
dc.subject.keywordDisorders of sex development-
dc.subject.keywordOvotesticular disorder-
dc.subject.keywordTrue hermaphrodite-
dc.contributor.alternativeNameKim, Hye In-
dc.contributor.affiliatedAuthor김혜인-
dc.contributor.affiliatedAuthor윤보현-
dc.contributor.affiliatedAuthor이용승-
dc.contributor.affiliatedAuthor이인하-
dc.contributor.affiliatedAuthor한상원-
dc.citation.volume34-
dc.citation.number5-
dc.citation.startPage626-
dc.citation.endPage630-
dc.identifier.bibliographicCitationJOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY, Vol.34(5) : 626-630, 2021-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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