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Treatment Patterns and Clinical Outcomes in Korean Cancer Patients With Venous Thromboembolism: A Retrospective Cohort Study

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dc.contributor.author홍민희-
dc.date.accessioned2021-10-21T00:07:01Z-
dc.date.available2021-10-21T00:07:01Z-
dc.date.issued2021-01-
dc.identifier.issn1076-0296-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/185383-
dc.description.abstractThis study assessed epidemiologic data and clinical outcomes, including venous thromboembolism (VTE) recurrence and bleeding events, in patients with cancer-associated VTE, and assessed factors associated with clinical outcomes. Data were extracted from retrospective medical-chart review of adult patients diagnosed with cancer-associated deep vein thrombosis or pulmonary embolism who received anticoagulation treatment for ≥3 months. Patients were classified by: low-molecular-weight heparin (LMWH), direct oral anticoagulants (DOACs), and other anticoagulants. First VTE recurrence and bleeding events, and factors associated with their occurrence, were assessed during the initial 6 months of treatment. Overall, 623 patients (age: 63.7 ± 11.3 years, 49.3% male) were included (119, 132, and 372 patients in LMWH, DOACs and other anticoagulants groups, respectively). The cumulative 6-month incidence of VTE recurrence was 16.6% (total), 8.3% (LMWH), 16.7% (DOACs), and 20.7% (other); respective bleeding events were 22.5%, 11.0%, 12.3%, and 30.7%). VTE recurrence and bleeding rates differed only between LMWH and other anticoagulants (HR 2.4, 95% CI: 1.2-5.0 and 3.6, 1.9-6.8, respectively). These results highlight the importance of initial VTE treatment choice for preventing VTE recurrence and bleeding events. LMWH or DOACs for ≥3 months can be considered for effective VTE management in cancer patients.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherSage Publications-
dc.relation.isPartOfCLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdministration, Oral-
dc.subject.MESHAged-
dc.subject.MESHAnticoagulants / administration & dosage-
dc.subject.MESHAnticoagulants / adverse effects-
dc.subject.MESHAnticoagulants / therapeutic use-
dc.subject.MESHCohort Studies-
dc.subject.MESHFemale-
dc.subject.MESHHemorrhage / etiology-
dc.subject.MESHHeparin, Low-Molecular-Weight / therapeutic use-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasms / complications*-
dc.subject.MESHPulmonary Embolism / drug therapy-
dc.subject.MESHPulmonary Embolism / etiology-
dc.subject.MESHRecurrence-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHVenous Thromboembolism / drug therapy*-
dc.subject.MESHVenous Thromboembolism / etiology*-
dc.titleTreatment Patterns and Clinical Outcomes in Korean Cancer Patients With Venous Thromboembolism: A Retrospective Cohort Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorSoo-Mee Bang-
dc.contributor.googleauthorJin-Hyoung Kang-
dc.contributor.googleauthorMin Hee Hong-
dc.contributor.googleauthorJin-Seok Ahn-
dc.contributor.googleauthorSo Yeon Oh-
dc.contributor.googleauthorJin Ho Baek-
dc.contributor.googleauthorYoon Ji Choi-
dc.contributor.googleauthorSeong Hoon Shin-
dc.contributor.googleauthorYoung-Joo Kim-
dc.contributor.googleauthorHa-Yeong Gil-
dc.contributor.googleauthorHyung-Eun Park-
dc.contributor.googleauthorJuneyoung Lee-
dc.contributor.googleauthorEun-Lyeong Park-
dc.identifier.doi10.1177/1076029620979575-
dc.contributor.localIdA04393-
dc.relation.journalcodeJ00546-
dc.identifier.eissn1938-2723-
dc.identifier.pmid33471574-
dc.identifier.urlhttps://journals.sagepub.com/doi/10.1177/1076029620979575-
dc.subject.keywordcancer-
dc.subject.keyworddirect oral anticoagulants-
dc.subject.keywordlow-molecular-weight heparin-
dc.subject.keywordvenous thromboembolism-
dc.contributor.alternativeNameHong, Min Hee-
dc.contributor.affiliatedAuthor홍민희-
dc.citation.volume27-
dc.citation.startPage1076029620979575-
dc.identifier.bibliographicCitationCLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, Vol.27 : 1076029620979575, 2021-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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