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Multidrug Resistance in Gram-Negative Bacteria isolated in a Tertiary-Care Hospital in Northern Ghana from 2017-2019
DC Field | Value | Language |
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dc.contributor.author | OSEI KENNEDY MENSAH | - |
dc.date.accessioned | 2021-10-20T02:31:06Z | - |
dc.date.available | 2021-10-20T02:31:06Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/185130 | - |
dc.description.abstract | Background: Multidrug resistance exist within a wide variety of clinically significant pathogens and poses a serious and growing global public health threat. This study aimed to determine the incidence, patterns, and trends of multidrug resistance of gram-negative bacterial isolates in clinical specimens cultured at the Tamale Teaching Hospital Laboratory. Methods: This retrospective study analyzed gram-negative bacteria isolates and sensitivity test results of patients who visited the Tamale Teaching Hospital laboratory in Ghana, West Africa from 2017 to 2019 Results: A total of 2769 gram-negative bacteria isolates and their phenotypic AST results were analyzed in this study. A total of 1297 gram-negative bacteria were isolated from urine samples representing 46.8% of all the isolates followed by isolates from sputum samples and wound swabs. Escherichia coli (23.8%) is the highest isolated gram-negative bacteria in all samples with, predominance from urine samples making up 33.2%. All gram-negative bacteria isolated from 2017-2019 showed significant multidrug resistance between 60% and 95.5%. Klebsiella pneumonia similarly showed increased multidrug resistance levels year on year; 2017(84%), 2018(89.5%) and 95.1% in 2019. Pseudomonas aeruginosa which showed relatively low multidrug resistance rates (65.8%) was, still determined to demonstrate increased resistance from 2017(59.5%) to 2019(78.7%). Gram-negative bacteria showed the highest susceptibility to antibiotics in the aminoglycoside group with amikacin the most effective. Enterobacter spp resistance to amikacin was as low as 16.2%, Escherichia coli (11.8%) and Klebsiella pneumoniae were determined to be 17.7%. Conclusion: The study has shown high levels of multidrug-resistant gram-negative bacteria commonly isolated as the causative organisms in a range of infections. There is high resistance to penicillins, cephalosporins, and fluoroquinolones among major gram-negative pathogens. Aminoglycosides exhibited the least levels of resistance to isolated gram-negative bacteria in the Tamale Teaching Hospital. | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | 연세대학교 | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Multidrug Resistance in Gram-Negative Bacteria isolated in a Tertiary-Care Hospital in Northern Ghana from 2017-2019 | - |
dc.type | Thesis | - |
dc.contributor.college | Graduate School of Public Health (보건대학원) | - |
dc.contributor.department | Graduate School of Public Health (보건대학원) | - |
dc.description.degree | 석사 | - |
dc.type.local | Thesis | - |
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