28 48

Cited 0 times in

Risk factors for neutropenic fever in non-Hodgkin's lymphoma patients with primary granulocyte colony-stimulating factor prophylaxis

Authors
 Yu Ri Kim  ;  Soo-Jeong Kim  ;  Yong Park  ;  Sung Yong Oh  ;  Hwan-Jung Yun  ;  Yeung-Chul Mun  ;  Jin Seok Kim 
Citation
 KOREAN JOURNAL OF INTERNAL MEDICINE, Vol.36(5) : 1181-1189, 2021-09 
Journal Title
KOREAN JOURNAL OF INTERNAL MEDICINE
ISSN
 1226-3303 
Issue Date
2021-09
MeSH
Aged ; Antineoplastic Combined Chemotherapy Protocols* / adverse effects ; Cyclophosphamide / adverse effects ; Doxorubicin / adverse effects ; Female ; Granulocyte Colony-Stimulating Factor / therapeutic use ; Humans ; Lymphoma, Non-Hodgkin* / drug therapy ; Middle Aged ; Prednisone / adverse effects ; Retrospective Studies ; Risk Factors ; Vincristine / adverse effects
Keywords
Albumin ; Elderly ; Febrile neutropenia ; Female ; Lymphoma, non-Hodgkin
Abstract
Background/aims: Febrile neutropenia (FN) interferes with the proper chemotherapy dose density or intensity in non-Hodgkin's lymphoma (NHL) patients. Chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) ± rituximab has an intermediate FN risk. Prophylactic granulocyte colony-stimulating factor (G-CSF) support is recommended for patients with other host-related risk factors. Methods: We evaluated the risk factors for FN-related admission in NHL patients who have received primary G-CSF (lenograstim) prophylaxis. Results: Data from 148 patients were analyzed. The incidence of neutropenic fever was 96 events (12.2%), and the median period was 3.85 days (range, 0 to 5.9); the median duration of neutropenia was 4.21 days (range, 3.3 to 5.07). Eighty-three FN-related admissions were reported. Advanced age (> 60 years), female sex, a low albumin level, and prednisone use were associated with FN-related admission in multivariable analysis (p = 0.010, p < 0.001, and p = 0.010, respectively). A comparison between diffuse large B-cell lymphoma patients treated with R-CHOP and pegylated G-CSF and those treated with R-CHOP and lenograstim did not reveal significant differences in the FN-related admission rate between the two groups, although the lenograstim-treated group had a higher incidence of severe neutropenia. Conclusion: Elderly patients, female patients, and patients with low albumin levels need to be actively followed-up for FN even when primary prophylaxis with G-CSF has been used.
Files in This Item:
T202104004.pdf Download
DOI
10.3904/kjim.2020.206
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Soo Jeong(김수정) ORCID logo https://orcid.org/0000-0001-8859-3573
Kim, Yu Ri(김유리) ORCID logo https://orcid.org/0000-0001-5505-0142
Kim, Jin Seok(김진석) ORCID logo https://orcid.org/0000-0001-8986-8436
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/185107
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links