Cited 10 times in
Dosimetric Comparison of Radiation Techniques for Comprehensive Regional Nodal Radiation Therapy for Left-Sided Breast Cancer: A Treatment Planning Study
DC Field | Value | Language |
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dc.contributor.author | 장지석 | - |
dc.contributor.author | 한민철 | - |
dc.contributor.author | 김용배 | - |
dc.contributor.author | 김진성 | - |
dc.date.accessioned | 2021-09-29T05:33:35Z | - |
dc.date.available | 2021-09-29T05:33:35Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/185098 | - |
dc.description.abstract | Purpose: How modern cardiac sparing techniques and beam delivery systems using advanced x-ray and proton beam therapy (PBT) can reduce incidental radiation exposure doses to cardiac and pulmonary organs individually or in any combination is poorly investigated. Methods: Among 15 patients with left-sided breast cancer, partial wide tangential 3D-conformal radiotherapy (3DCRT) delivered in conventional fractionation (CF) or hypofractionated (HF) schedules; PBT delivered in a CF schedule; and volumetric modulated arc therapy (VMAT) delivered in an HF schedule, each under continuous positive airway pressure (CPAP) and free-breathing (FB) conditions, were examined. Target volume coverage and doses to organs-at-risk (OARs) were calculated for each technique. Outcomes were compared with one-way analysis of variance and the Bonferroni test, with p-values <0.05 considered significant. Results: Target volume coverage was within acceptable levels in all interventions, except for the internal mammary lymph node D95 (99% in PBT, 90% in VMAT-CPAP, 84% in VMAT-FB, and 74% in 3DCRT). The mean heart dose (MHD) was the lowest in PBT (<1 Gy) and VMAT-CPAP (2.2 Gy) and the highest in 3DCRT with CF/FB (7.8 Gy), respectively. The mean lung dose (MLD) was the highest in 3DCRT-CF-FB (20 Gy) and the lowest in both VMAT-HF-CPAP and PBT (approximately 5-6 Gy). VMAT-HF-CPAP and PBT delivered a comparable maximum dose to the left ascending artery (7.2 and 6.13 Gy, respectively). Conclusions: Both proton and VMAT in combination with CPAP can minimize the radiation exposure to heart and lung with optimal target coverage in regional RT for left-sided breast cancer. The clinical relevance of these differences is yet to be elucidated. Continued efforts are needed to minimize radiation exposures during RT treatment to maximize its therapeutic index. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Frontiers Research Foundation | - |
dc.relation.isPartOf | FRONTIERS IN ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Dosimetric Comparison of Radiation Techniques for Comprehensive Regional Nodal Radiation Therapy for Left-Sided Breast Cancer: A Treatment Planning Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiation Oncology (방사선종양학교실) | - |
dc.contributor.googleauthor | Heejoo Ko | - |
dc.contributor.googleauthor | Jee Suk Chang | - |
dc.contributor.googleauthor | Jin Young Moon | - |
dc.contributor.googleauthor | Won Hee Lee | - |
dc.contributor.googleauthor | Chirag Shah | - |
dc.contributor.googleauthor | Jin Sup Andy Shim | - |
dc.contributor.googleauthor | Min Cheol Han | - |
dc.contributor.googleauthor | Jong Geol Baek | - |
dc.contributor.googleauthor | Ryeong Hwang Park | - |
dc.contributor.googleauthor | Yong Bae Kim | - |
dc.contributor.googleauthor | Jin Sung Kim | - |
dc.identifier.doi | 10.3389/fonc.2021.645328 | - |
dc.contributor.localId | A04658 | - |
dc.contributor.localId | A05870 | - |
dc.contributor.localId | A00744 | - |
dc.contributor.localId | A04548 | - |
dc.relation.journalcode | J03512 | - |
dc.identifier.eissn | 2234-943X | - |
dc.identifier.pmid | 33912459 | - |
dc.subject.keyword | breast neoplasms | - |
dc.subject.keyword | continuous positive airway pressure | - |
dc.subject.keyword | intensity-modulated | - |
dc.subject.keyword | proton therapy | - |
dc.subject.keyword | radiotherapy | - |
dc.contributor.alternativeName | Chang, Jee Suk | - |
dc.contributor.affiliatedAuthor | 장지석 | - |
dc.contributor.affiliatedAuthor | 한민철 | - |
dc.contributor.affiliatedAuthor | 김용배 | - |
dc.contributor.affiliatedAuthor | 김진성 | - |
dc.citation.volume | 11 | - |
dc.citation.startPage | 645328 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN ONCOLOGY, Vol.11 : 645328, 2021-04 | - |
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