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Dosimetric Comparison of Radiation Techniques for Comprehensive Regional Nodal Radiation Therapy for Left-Sided Breast Cancer: A Treatment Planning Study

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dc.contributor.author장지석-
dc.contributor.author한민철-
dc.contributor.author김용배-
dc.contributor.author김진성-
dc.date.accessioned2021-09-29T05:33:35Z-
dc.date.available2021-09-29T05:33:35Z-
dc.date.issued2021-04-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/185098-
dc.description.abstractPurpose: How modern cardiac sparing techniques and beam delivery systems using advanced x-ray and proton beam therapy (PBT) can reduce incidental radiation exposure doses to cardiac and pulmonary organs individually or in any combination is poorly investigated. Methods: Among 15 patients with left-sided breast cancer, partial wide tangential 3D-conformal radiotherapy (3DCRT) delivered in conventional fractionation (CF) or hypofractionated (HF) schedules; PBT delivered in a CF schedule; and volumetric modulated arc therapy (VMAT) delivered in an HF schedule, each under continuous positive airway pressure (CPAP) and free-breathing (FB) conditions, were examined. Target volume coverage and doses to organs-at-risk (OARs) were calculated for each technique. Outcomes were compared with one-way analysis of variance and the Bonferroni test, with p-values <0.05 considered significant. Results: Target volume coverage was within acceptable levels in all interventions, except for the internal mammary lymph node D95 (99% in PBT, 90% in VMAT-CPAP, 84% in VMAT-FB, and 74% in 3DCRT). The mean heart dose (MHD) was the lowest in PBT (<1 Gy) and VMAT-CPAP (2.2 Gy) and the highest in 3DCRT with CF/FB (7.8 Gy), respectively. The mean lung dose (MLD) was the highest in 3DCRT-CF-FB (20 Gy) and the lowest in both VMAT-HF-CPAP and PBT (approximately 5-6 Gy). VMAT-HF-CPAP and PBT delivered a comparable maximum dose to the left ascending artery (7.2 and 6.13 Gy, respectively). Conclusions: Both proton and VMAT in combination with CPAP can minimize the radiation exposure to heart and lung with optimal target coverage in regional RT for left-sided breast cancer. The clinical relevance of these differences is yet to be elucidated. Continued efforts are needed to minimize radiation exposures during RT treatment to maximize its therapeutic index.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherFrontiers Research Foundation-
dc.relation.isPartOfFRONTIERS IN ONCOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleDosimetric Comparison of Radiation Techniques for Comprehensive Regional Nodal Radiation Therapy for Left-Sided Breast Cancer: A Treatment Planning Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학교실)-
dc.contributor.googleauthorHeejoo Ko-
dc.contributor.googleauthorJee Suk Chang-
dc.contributor.googleauthorJin Young Moon-
dc.contributor.googleauthorWon Hee Lee-
dc.contributor.googleauthorChirag Shah-
dc.contributor.googleauthorJin Sup Andy Shim-
dc.contributor.googleauthorMin Cheol Han-
dc.contributor.googleauthorJong Geol Baek-
dc.contributor.googleauthorRyeong Hwang Park-
dc.contributor.googleauthorYong Bae Kim-
dc.contributor.googleauthorJin Sung Kim-
dc.identifier.doi10.3389/fonc.2021.645328-
dc.contributor.localIdA04658-
dc.contributor.localIdA05870-
dc.contributor.localIdA00744-
dc.contributor.localIdA04548-
dc.relation.journalcodeJ03512-
dc.identifier.eissn2234-943X-
dc.identifier.pmid33912459-
dc.subject.keywordbreast neoplasms-
dc.subject.keywordcontinuous positive airway pressure-
dc.subject.keywordintensity-modulated-
dc.subject.keywordproton therapy-
dc.subject.keywordradiotherapy-
dc.contributor.alternativeNameChang, Jee Suk-
dc.contributor.affiliatedAuthor장지석-
dc.contributor.affiliatedAuthor한민철-
dc.contributor.affiliatedAuthor김용배-
dc.contributor.affiliatedAuthor김진성-
dc.citation.volume11-
dc.citation.startPage645328-
dc.identifier.bibliographicCitationFRONTIERS IN ONCOLOGY, Vol.11 : 645328, 2021-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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