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SAMP1/Klotho-결핍 마우스의 하악골에서 골형성이상
DC Field | Value | Language |
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dc.contributor.author | 육종인 | - |
dc.date.accessioned | 2021-09-29T02:37:17Z | - |
dc.date.available | 2021-09-29T02:37:17Z | - |
dc.date.issued | 2020-08 | - |
dc.identifier.issn | 1225-1577 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/185034 | - |
dc.description.abstract | Aging is a physiological change that leads to a decline in biological functions from metabolic stress. To investigate the effect of aging on mandibular bone formation, we created SAMP1/Klotho-deficient mice and performed micro-computed tomography (micro-CT) and histology analyses in 4-or 8 week-old SAMP1/kl -/- mice. SAMP1/kl -/- mice exhibited extensive inflammation, tissue calcification, and abnormal mandibular bone development. Using micro-CT analysis, SAMP1/kl -/- mice displayed a loss of incisor roots and irregular dentinal tubule formation, as well as calcification within the pulp root canal. Furthermore, the mandibular ramus showed extensive ground glass appearance in SAMP1/kl -/- mice. In histological analysis, we found calcified skeletal structures and dysplastic bone formation in SAMP1/kl -/- mice. These results provide an understanding of the pathologic alterations of aging-related mandibular bone. SAMP1/kl -/- mice may serve as a novel model for dysosteogenesis in mandibular bone development. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한구강악안면병리학회 | - |
dc.relation.isPartOf | Korean Journal of Oral and Maxillofacial Pathology(대한구강악안면병리학회지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | SAMP1/Klotho-결핍 마우스의 하악골에서 골형성이상 | - |
dc.title.alternative | Dysosteogenesis in the Mandibular Bone of SAMP1/Klotho-Deficient Mice | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Pathology (구강병리학교실) | - |
dc.contributor.googleauthor | 육종인 | - |
dc.contributor.googleauthor | Nguyen Khanh Toan | - |
dc.contributor.googleauthor | 서요섭 | - |
dc.contributor.googleauthor | 유상준 | - |
dc.contributor.googleauthor | 안상건 | - |
dc.identifier.doi | 10.17779/KAOMP.2020.44.4.001 | - |
dc.contributor.localId | A02536 | - |
dc.relation.journalcode | J02084 | - |
dc.subject.keyword | SAMP1/ Klotho | - |
dc.subject.keyword | Aging | - |
dc.subject.keyword | Dysosteogenesis | - |
dc.subject.keyword | Mandibular bone | - |
dc.subject.keyword | Bone development | - |
dc.contributor.alternativeName | Yook, Jong In | - |
dc.contributor.affiliatedAuthor | 육종인 | - |
dc.citation.volume | 44 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 103 | - |
dc.citation.endPage | 112 | - |
dc.identifier.bibliographicCitation | Korean Journal of Oral and Maxillofacial Pathology (대한구강악안면병리학회지), Vol.44(4) : 103-112, 2020-08 | - |
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