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SAMP1/Klotho-결핍 마우스의 하악골에서 골형성이상

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dc.contributor.author육종인-
dc.date.accessioned2021-09-29T02:37:17Z-
dc.date.available2021-09-29T02:37:17Z-
dc.date.issued2020-08-
dc.identifier.issn1225-1577-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/185034-
dc.description.abstractAging is a physiological change that leads to a decline in biological functions from metabolic stress. To investigate the effect of aging on mandibular bone formation, we created SAMP1/Klotho-deficient mice and performed micro-computed tomography (micro-CT) and histology analyses in 4-or 8 week-old SAMP1/kl -/- mice. SAMP1/kl -/- mice exhibited extensive inflammation, tissue calcification, and abnormal mandibular bone development. Using micro-CT analysis, SAMP1/kl -/- mice displayed a loss of incisor roots and irregular dentinal tubule formation, as well as calcification within the pulp root canal. Furthermore, the mandibular ramus showed extensive ground glass appearance in SAMP1/kl -/- mice. In histological analysis, we found calcified skeletal structures and dysplastic bone formation in SAMP1/kl -/- mice. These results provide an understanding of the pathologic alterations of aging-related mandibular bone. SAMP1/kl -/- mice may serve as a novel model for dysosteogenesis in mandibular bone development.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한구강악안면병리학회-
dc.relation.isPartOfKorean Journal of Oral and Maxillofacial Pathology(대한구강악안면병리학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleSAMP1/Klotho-결핍 마우스의 하악골에서 골형성이상-
dc.title.alternativeDysosteogenesis in the Mandibular Bone of SAMP1/Klotho-Deficient Mice-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Pathology (구강병리학교실)-
dc.contributor.googleauthor육종인-
dc.contributor.googleauthorNguyen Khanh Toan-
dc.contributor.googleauthor서요섭-
dc.contributor.googleauthor유상준-
dc.contributor.googleauthor안상건-
dc.identifier.doi10.17779/KAOMP.2020.44.4.001-
dc.contributor.localIdA02536-
dc.relation.journalcodeJ02084-
dc.subject.keywordSAMP1/ Klotho-
dc.subject.keywordAging-
dc.subject.keywordDysosteogenesis-
dc.subject.keywordMandibular bone-
dc.subject.keywordBone development-
dc.contributor.alternativeNameYook, Jong In-
dc.contributor.affiliatedAuthor육종인-
dc.citation.volume44-
dc.citation.number4-
dc.citation.startPage103-
dc.citation.endPage112-
dc.identifier.bibliographicCitationKorean Journal of Oral and Maxillofacial Pathology (대한구강악안면병리학회지), Vol.44(4) : 103-112, 2020-08-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers

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