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SAMP1/Klotho-결핍 마우스의 하악골에서 골형성이상

Other Titles
 Dysosteogenesis in the Mandibular Bone of SAMP1/Klotho-Deficient Mice 
Authors
 육종인  ;  Nguyen Khanh Toan  ;  서요섭  ;  유상준  ;  안상건 
Citation
 Korean Journal of Oral and Maxillofacial Pathology (대한구강악안면병리학회지), Vol.44(4) : 103-112, 2020-08 
Journal Title
Korean Journal of Oral and Maxillofacial Pathology(대한구강악안면병리학회지)
ISSN
 1225-1577 
Issue Date
2020-08
Keywords
SAMP1/ Klotho ; Aging ; Dysosteogenesis ; Mandibular bone ; Bone development
Abstract
Aging is a physiological change that leads to a decline in biological functions from metabolic stress. To investigate the effect of aging on mandibular bone formation, we created SAMP1/Klotho-deficient mice and performed micro-computed tomography (micro-CT) and histology analyses in 4-or 8 week-old SAMP1/kl -/- mice. SAMP1/kl -/- mice exhibited extensive inflammation, tissue calcification, and abnormal mandibular bone development. Using micro-CT analysis, SAMP1/kl -/- mice displayed a loss of incisor roots and irregular dentinal tubule formation, as well as calcification within the pulp root canal. Furthermore, the mandibular ramus showed extensive ground glass appearance in SAMP1/kl -/- mice. In histological analysis, we found calcified skeletal structures and dysplastic bone formation in SAMP1/kl -/- mice. These results provide an understanding of the pathologic alterations of aging-related mandibular bone. SAMP1/kl -/- mice may serve as a novel model for dysosteogenesis in mandibular bone development.
Files in This Item:
T999202358.pdf Download
DOI
10.17779/KAOMP.2020.44.4.001
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
Yonsei Authors
Yook, Jong In(육종인) ORCID logo https://orcid.org/0000-0002-7318-6112
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/185034
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