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Validation of the D: A: D Chronic Kidney Disease Risk Score Model Among People Living With HIV in the Asia-Pacific
DC Field | Value | Language |
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dc.contributor.author | 최준용 | - |
dc.date.accessioned | 2021-09-29T02:35:11Z | - |
dc.date.available | 2021-09-29T02:35:11Z | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 1525-4135 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/185007 | - |
dc.description.abstract | Background: We validated the Data collection on Adverse events of anti-HIV Drugs (D:A:D) full-risk and short-risk score models for chronic kidney disease (CKD) in the Asian HIV cohorts. Settings: A validation study among people living with HIV (PLHIV) aged ≥18 years among the cohorts in the Asia-Pacific region. Methods: PLHIV with a baseline estimated glomerular filtration rate > 60 mL/min/1.73 m were included for validation of the D:A:D CKD full version and short version without cardiovascular risk factors. Those with <3 estimated glomerular filtration rate measurements from baseline or previous exposure to potentially nephrotoxic antiretrovirals were excluded. Kaplan-Meier methods were used to estimate the probability of CKD development. The area under the receiver operating characteristics was also used to validate the risk score. Results: We included 5701 participants in full model {median 8.1 [interquartile range (IQR) 4.8-10.9] years follow-up} and 9791 in short model validation [median 4.9 (IQR 2.5-7.3) years follow-up]. The crude incidence rate of CKD was 8.1 [95% confidence interval (CI): 7.3 to 8.9] per 1000 person-years in the full model cohort and 10.5 (95% CI: 9.6 to 11.4) per 1000 person-years in the short model cohort. The progression rates for CKD at 10 years in the full model cohort were 2.7%, 8.9%, and 26.1% for low-risk, medium-risk, and high-risk groups, and 3.5%, 11.7%, and 32.4% in the short model cohort. The area under the receiver operating characteristics for the full-risk and short-risk score was 0.81 (95% CI: 0.79 to 0.83) and 0.83 (95% CI: 0.81 to 0.85), respectively. Conclusion: The D:A:D CKD full-risk and short-risk score performed well in predicting CKD events among Asian PLHIV. These risk prediction models may be useful to assist clinicians in identifying individuals at high risk of developing CKD. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins, Inc. | - |
dc.relation.isPartOf | JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Anti-HIV Agents / adverse effects* | - |
dc.subject.MESH | Asia, Southeastern | - |
dc.subject.MESH | Far East | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glomerular Filtration Rate | - |
dc.subject.MESH | HIV Infections / complications* | - |
dc.subject.MESH | HIV-1* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Renal Insufficiency, Chronic / chemically induced* | - |
dc.subject.MESH | Renal Insufficiency, Chronic / pathology | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Validation of the D: A: D Chronic Kidney Disease Risk Score Model Among People Living With HIV in the Asia-Pacific | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Win Min Han | - |
dc.contributor.googleauthor | Rimke Bijker | - |
dc.contributor.googleauthor | Ezhilarasi Chandrasekaran | - |
dc.contributor.googleauthor | Sanjay Pujari | - |
dc.contributor.googleauthor | Oon Tek Ng | - |
dc.contributor.googleauthor | Penh Sun Ly | - |
dc.contributor.googleauthor | Man-Po Lee | - |
dc.contributor.googleauthor | Kinh Van Nguyen | - |
dc.contributor.googleauthor | Yu-Jiun Chan | - |
dc.contributor.googleauthor | Cuong Duy Do | - |
dc.contributor.googleauthor | Jun Yong Choi | - |
dc.contributor.googleauthor | Romanee Chaiwarith | - |
dc.contributor.googleauthor | Tuti Parwati Merati | - |
dc.contributor.googleauthor | Sasisopin Kiertiburanakul | - |
dc.contributor.googleauthor | Iskandar Azwa | - |
dc.contributor.googleauthor | Suwimon Khusuwan | - |
dc.contributor.googleauthor | Fujie Zhang | - |
dc.contributor.googleauthor | Yasmin Mohamed Gani | - |
dc.contributor.googleauthor | Junko Tanuma | - |
dc.contributor.googleauthor | Shashikala Sangle | - |
dc.contributor.googleauthor | Rossana Ditangco | - |
dc.contributor.googleauthor | Evy Yunihastuti | - |
dc.contributor.googleauthor | Jeremy Ross | - |
dc.contributor.googleauthor | Anchalee Avihingsanon | - |
dc.identifier.doi | 10.1097/QAI.0000000000002464 | - |
dc.contributor.localId | A04191 | - |
dc.relation.journalcode | J01195 | - |
dc.identifier.eissn | 1944-7884 | - |
dc.identifier.pmid | 33136750 | - |
dc.identifier.url | https://journals.lww.com/jaids/Fulltext/2020/12010/Validation_of_the_D_A_D_Chronic_Kidney_Disease.16.aspx | - |
dc.contributor.alternativeName | Choi, Jun Yong | - |
dc.contributor.affiliatedAuthor | 최준용 | - |
dc.citation.volume | 85 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 489 | - |
dc.citation.endPage | 497 | - |
dc.identifier.bibliographicCitation | JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol.85(4) : 489-497, 2020-12 | - |
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