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Prospective partially randomized comparison of clopidogrel loading versus maintenance dosing to prevent periprocedural myocardial infarction after stenting for stable angina pectoris: Results from the "Method of Clopidogrel Pre-treatment Undergoing Conventional Coronary Angiogram in Angina Patients (MECCA)" study
DC Field | Value | Language |
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dc.contributor.author | 안철민 | - |
dc.date.accessioned | 2021-09-29T02:32:22Z | - |
dc.date.available | 2021-09-29T02:32:22Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | 0946-1965 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184971 | - |
dc.description.abstract | What is known and objective: Pre-treatment of clopidogrel 600 mg is better than 300 mg loading for reducing periprocedural myocardial infarction (PMI). We aimed to evaluate pre-treatment methods for preventing PMI among patients undergoing conventional coronary angiography (CAG) for stable angina pectoris. Materials and methods: The study analyzed 402 patients who underwent percutaneous coronary intervention (PCI) during 2010 - 2011 at three Korean hospitals. Clopidogrel-naïve patients received routine maintenance therapy (75 mg/day for ≥ 5 days) and were randomly assigned to a 300-mg reload (RL) or only the maintenance dose (MD). Patients who received a loading dose (LD; 600 mg at 2 - 24 hours before the procedure) were entered into a non-randomized group. Results: After excluding patients who showed an abnormal creatinine kinase myocardial band (CK-MB) level, the study included 233 patients in the LD group, 85 patients in the RL group and 84 patients in the MD group. The LD group had a significantly higher rate of PMI (LD: 21, RL: 3, MD: 0 cases; p = 0.007) and a significant increase in the mean CK-MB levels after 8 hours (p = 0.016) and 24 h (p = 0.01). However, there was no difference in PMI between the RL and MD groups. Furthermore, no significant differences between the three groups were observed in the P2Y12 reaction unit (PRU) values (p = 0.57). Albeit not significantly, the LD group had a higher rate of moderate-to-severe GUSTO bleeding within 7 days. What is new and conclusion: Clopidogrel maintenance is better than 600-mg loading for preventing PMI, and the RL protocol did not further prevent PMI. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Dustri-Verlag Dr. K. Feistle | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Angina, Stable* | - |
dc.subject.MESH | Clopidogrel | - |
dc.subject.MESH | Coronary Angiography | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Myocardial Infarction* | - |
dc.subject.MESH | Percutaneous Coronary Intervention* | - |
dc.subject.MESH | Platelet Aggregation Inhibitors | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Stents | - |
dc.subject.MESH | Ticlopidine | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Prospective partially randomized comparison of clopidogrel loading versus maintenance dosing to prevent periprocedural myocardial infarction after stenting for stable angina pectoris: Results from the "Method of Clopidogrel Pre-treatment Undergoing Conventional Coronary Angiogram in Angina Patients (MECCA)" study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jae Hyoung Park | - |
dc.contributor.googleauthor | Je Sang Kim | - |
dc.contributor.googleauthor | Chul-Min Ahn | - |
dc.contributor.googleauthor | Soon Jun Hong | - |
dc.contributor.googleauthor | Kyung Joo Ahn | - |
dc.contributor.googleauthor | Jae Woong Choi | - |
dc.contributor.googleauthor | Hyung Joon Joo | - |
dc.contributor.googleauthor | Cheol Woong Yu | - |
dc.contributor.googleauthor | Do-Sun Lim | - |
dc.identifier.doi | 10.5414/CP203644 | - |
dc.contributor.localId | A05648 | - |
dc.relation.journalcode | J01098 | - |
dc.identifier.pmid | 32589129 | - |
dc.identifier.url | https://www.dustri.com/nc/article-response-page.html?artId=186815&doi= | - |
dc.citation.volume | 58 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 523 | - |
dc.citation.endPage | 530 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, Vol.58(10) : 523-530, 2020-10 | - |
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