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Impact of skull density ratio on efficacy and safety of magnetic resonance-guided focused ultrasound treatment of essential tremor

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dc.contributor.author장진우-
dc.date.accessioned2021-09-29T02:29:34Z-
dc.date.available2021-09-29T02:29:34Z-
dc.date.issued2020-04-
dc.identifier.issn0022-3085-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184934-
dc.description.abstractObjective: Skull density ratio (SDR) assesses the transparency of the skull to ultrasound. Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy in essential tremor (ET) patients with a lower SDR may be less effective, and the risk for complications may be increased. To address these questions, the authors analyzed clinical outcomes of MRgFUS thalamotomy based on SDRs. Methods: In 189 patients, 3 outcomes were correlated with SDRs. Efficacy was based on improvement in Clinical Rating Scale for Tremor (CRST) scores 1 year after MRgFUS. Procedural efficiency was determined by the ease of achieving a peak voxel temperature of 54°C. Safety was based on the rate of the most severe procedure-related adverse event. SDRs were categorized at thresholds of 0.45 and 0.40, selected based on published criteria. Results: Of 189 patients, 53 (28%) had an SDR < 0.45 and 20 (11%) had an SDR < 0.40. There was no significant difference in improvement in CRST scores between those with an SDR ≥ 0.45 (58% ± 24%), 0.40 ≤ SDR < 0.45 (i.e., SDR ≥ 0.40 but < 0.45) (63% ± 27%), and SDR < 0.40 (49% ± 28%; p = 0.0744). Target temperature was achieved more often in those with an SDR ≥ 0.45 (p < 0.001). Rates of adverse events were lower in the groups with an SDR < 0.45 (p = 0.013), with no severe adverse events in these groups. Conclusions: MRgFUS treatment of ET can be effectively and safely performed in patients with an SDR < 0.45 and an SDR < 0.40, although the procedure is more efficient when SDR ≥ 0.45.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherAmerican Association of Neurological Surgeons-
dc.relation.isPartOfJOURNAL OF NEUROSURGERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleImpact of skull density ratio on efficacy and safety of magnetic resonance-guided focused ultrasound treatment of essential tremor-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurosurgery (신경외과학교실)-
dc.contributor.googleauthorMarissa D'Souza-
dc.contributor.googleauthorKevin S Chen-
dc.contributor.googleauthorJarrett Rosenberg-
dc.contributor.googleauthorW Jeffrey Elias-
dc.contributor.googleauthorHoward M Eisenberg-
dc.contributor.googleauthorRyder Gwinn-
dc.contributor.googleauthorTakaomi Taira-
dc.contributor.googleauthorJin Woo Chang-
dc.contributor.googleauthorNir Lipsman-
dc.contributor.googleauthorVibhor Krishna-
dc.contributor.googleauthorKeiji Igase-
dc.contributor.googleauthorKazumichi Yamada-
dc.contributor.googleauthorHaruhiko Kishima-
dc.contributor.googleauthorRees Cosgrove-
dc.contributor.googleauthorJordi Rumià-
dc.contributor.googleauthorMichael G Kaplitt-
dc.contributor.googleauthorHidehiro Hirabayashi-
dc.contributor.googleauthorDipankar Nandi-
dc.contributor.googleauthorJaimie M Henderson-
dc.contributor.googleauthorKim Butts Pauly-
dc.contributor.googleauthorMor Dayan-
dc.contributor.googleauthorCasey H Halpern-
dc.contributor.googleauthorPejman Ghanouni-
dc.identifier.doi10.3171/2019.2.JNS183517-
dc.contributor.localIdA03484-
dc.relation.journalcodeJ01636-
dc.identifier.eissn1933-0693-
dc.identifier.pmid31026836-
dc.identifier.urlhttps://thejns.org/view/journals/j-neurosurg/132/5/article-p1392.xml-
dc.subject.keywordET-
dc.subject.keywordMRgFUS-
dc.subject.keywordSDR-
dc.subject.keywordfunctional neurosurgery-
dc.subject.keywordmagnetic resonance-guided focused ultrasound-
dc.subject.keywordskull density ratio-
dc.contributor.alternativeNameChang, Jin Woo-
dc.contributor.affiliatedAuthor장진우-
dc.citation.volume132-
dc.citation.number5-
dc.citation.startPage1392-
dc.citation.endPage1397-
dc.identifier.bibliographicCitationJOURNAL OF NEUROSURGERY, Vol.132(5) : 1392-1397, 2020-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

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