Cited 11 times in
Development of A4 antibody for detection of neuraminidase I223R/H275Y-associated antiviral multidrug-resistant influenza virus
DC Field | Value | Language |
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dc.contributor.author | 용동은 | - |
dc.date.accessioned | 2021-09-29T02:28:28Z | - |
dc.date.available | 2021-09-29T02:28:28Z | - |
dc.date.issued | 2020-07 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184920 | - |
dc.description.abstract | The emergence and spread of antiviral drug-resistant viruses have been a worldwide challenge and a great concern for patient care. We report A4 antibody specifically recognizing and binding to the mutant I223R/H275Y neuraminidase and prove the applicability of A4 antibody for direct detection of antiviral multidrug-resistant viruses in various sensing platforms, including naked-eye detection, surface-enhanced Raman scattering-based immunoassay, and lateral flow system. The development of the A4 antibody enables fast, simple, and reliable point-of-care assays of antiviral multidrug-resistant influenza viruses. In addition to current influenza virus infection testing methods that do not provide information on the antiviral drug-resistance of the virus, diagnostic tests for antiviral multidrug-resistant viruses will improve clinical judgment in the treatment of influenza virus infections, avoid the unnecessary prescription of ineffective drugs, and improve current therapies. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Nature Pub. Group | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Amino Acid Sequence | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antibodies, Monoclonal / chemistry | - |
dc.subject.MESH | Antibodies, Monoclonal / immunology | - |
dc.subject.MESH | Antibodies, Viral / chemistry | - |
dc.subject.MESH | Antibodies, Viral / immunology* | - |
dc.subject.MESH | Antibody Affinity / immunology | - |
dc.subject.MESH | Antigens, Viral / metabolism | - |
dc.subject.MESH | Body Fluids / virology | - |
dc.subject.MESH | DNA Mutational Analysis | - |
dc.subject.MESH | Dogs | - |
dc.subject.MESH | Drug Resistance, Multiple / immunology* | - |
dc.subject.MESH | Drug Resistance, Viral / immunology* | - |
dc.subject.MESH | Epitopes / chemistry | - |
dc.subject.MESH | Epitopes / immunology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Influenza A Virus, H1N1 Subtype / enzymology | - |
dc.subject.MESH | Influenza A Virus, H1N1 Subtype / immunology* | - |
dc.subject.MESH | Influenza A Virus, H3N2 Subtype / enzymology | - |
dc.subject.MESH | Influenza A Virus, H3N2 Subtype / immunology* | - |
dc.subject.MESH | Madin Darby Canine Kidney Cells | - |
dc.subject.MESH | Molecular Docking Simulation | - |
dc.subject.MESH | Mutation / genetics* | - |
dc.subject.MESH | Neuraminidase / genetics* | - |
dc.subject.MESH | Optical Imaging | - |
dc.subject.MESH | Protein Binding | - |
dc.subject.MESH | Spectrum Analysis, Raman | - |
dc.title | Development of A4 antibody for detection of neuraminidase I223R/H275Y-associated antiviral multidrug-resistant influenza virus | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Kyeonghye Guk | - |
dc.contributor.googleauthor | Hyeran Kim | - |
dc.contributor.googleauthor | Miyeon Lee | - |
dc.contributor.googleauthor | Yoon-Aa Choi | - |
dc.contributor.googleauthor | Seul Gee Hwang | - |
dc.contributor.googleauthor | Gaon Han | - |
dc.contributor.googleauthor | Hye-Nan Kim | - |
dc.contributor.googleauthor | Hongki Kim | - |
dc.contributor.googleauthor | Hwangseo Park | - |
dc.contributor.googleauthor | Dongeun Yong | - |
dc.contributor.googleauthor | Taejoon Kang | - |
dc.contributor.googleauthor | Eun-Kyung Lim | - |
dc.contributor.googleauthor | Juyeon Jung | - |
dc.identifier.doi | 10.1038/s41467-020-17246-w | - |
dc.contributor.localId | A02423 | - |
dc.contributor.localId | A04616 | - |
dc.relation.journalcode | J02293 | - |
dc.identifier.eissn | 2041-1723 | - |
dc.identifier.pmid | 32647286 | - |
dc.contributor.alternativeName | Yong, Dong Eun | - |
dc.contributor.affiliatedAuthor | 용동은 | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 3418 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, Vol.11(1) : 3418, 2020-07 | - |
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