Cited 2 times in
Short-term therapy with anti-ICAM-1 monoclonal antibody induced long-term liver allograft survival in nonhuman primates
DC Field | Value | Language |
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dc.contributor.author | 양재석 | - |
dc.date.accessioned | 2021-09-29T02:25:13Z | - |
dc.date.available | 2021-09-29T02:25:13Z | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 1600-6135 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184880 | - |
dc.description.abstract | Tolerance induction remains challenging following liver transplantation and the long-term use of immunosuppressants, especially calcineurin inhibitors, leads to serious complications. We aimed to test an alternative immunosuppressant, a chimeric anti-ICAM-1 monoclonal antibody, MD-3, for improving the outcomes of liver transplantation. We used a rhesus macaque liver transplantation model and monkeys were divided into three groups: no immunosuppression (n = 2), conventional immunosuppression (n = 4), and MD-3 (n = 5). Without immunosuppression, liver allografts failed within a week by acute rejection. Sixteen-week-long conventional immunosuppression that consisted of prednisolone, tacrolimus, and an mTOR inhibitor prolonged liver allograft survival; however, recipients died of acute T cell-mediated rejection (day 52), chronic rejection (days 62 and 66), or adverse effects of mTOR inhibitor (day 32). In contrast, 12-week-long MD-3 therapy with transient conventional immunosuppression in the MD-3 group significantly prolonged the survival of liver allograft recipients (5, 96, 216, 412, 730 days; p = .0483). MD-3 effectively suppressed intragraft inflammatory cell infiltration, anti-donor T cell responses, and donor-specific antibody with intact anti-cytomegalovirus antibody responses. However, this regimen ended in chronic rejection. In conclusion, short-term therapy with MD-3 markedly improved liver allograft survival to 2 years without maintenance of immunosuppressant. MD-3 is therefore a promising immune-modulating agent for liver transplantation. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley-Blackwell | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF TRANSPLANTATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Short-term therapy with anti-ICAM-1 monoclonal antibody induced long-term liver allograft survival in nonhuman primates | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Suk Kyun Hong | - |
dc.contributor.googleauthor | Dongkyu Han | - |
dc.contributor.googleauthor | Sun-Kyung Lee | - |
dc.contributor.googleauthor | Jiyeon Kim | - |
dc.contributor.googleauthor | Eung-Soo Hwang | - |
dc.contributor.googleauthor | Haeryoung Kim | - |
dc.contributor.googleauthor | Jae-Il Lee | - |
dc.contributor.googleauthor | Kwangpyo Hong | - |
dc.contributor.googleauthor | Eui Soo Han | - |
dc.contributor.googleauthor | Jae-Hyung Cho | - |
dc.contributor.googleauthor | Jeong-Moo Lee | - |
dc.contributor.googleauthor | YoungRok Choi | - |
dc.contributor.googleauthor | Kwang-Woong Lee | - |
dc.contributor.googleauthor | Nam-Joon Yi | - |
dc.contributor.googleauthor | Jaeseok Yang | - |
dc.contributor.googleauthor | Kyung-Suk Suh | - |
dc.identifier.doi | 10.1111/ajt.16486 | - |
dc.contributor.localId | A06130 | - |
dc.relation.journalcode | J00121 | - |
dc.identifier.eissn | 1600-6143 | - |
dc.identifier.pmid | 33423374 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/ajt.16486 | - |
dc.subject.keyword | clinical research / practice, pancreas / simultaneous pancreas-kidney transplantation | - |
dc.subject.keyword | dclinical decision-making | - |
dc.subject.keyword | diabetes: type 2, diabetes : new onset / posttransplant | - |
dc.subject.keyword | endocrinology / diabetology | - |
dc.subject.keyword | health services and outcomes research | - |
dc.subject.keyword | immunosuppression / immune modulation | - |
dc.subject.keyword | obesity | - |
dc.subject.keyword | recipient selection | - |
dc.contributor.alternativeName | Yang, Jaeseok | - |
dc.contributor.affiliatedAuthor | 양재석 | - |
dc.citation.volume | 21 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 2978 | - |
dc.citation.endPage | 2991 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF TRANSPLANTATION, Vol.21(9) : 2978-2991, 2021-09 | - |
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