Cited 5 times in
Molecular epidemiology and clinical risk factors for rifaximin-non-susceptible Clostridioides difficile infection in South Korea: a prospective, multicentre, observational study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김도균 | - |
dc.contributor.author | 김희정 | - |
dc.contributor.author | 박윤수 | - |
dc.contributor.author | 정석훈 | - |
dc.date.accessioned | 2021-09-29T02:24:30Z | - |
dc.date.available | 2021-09-29T02:24:30Z | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 2213-7165 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184873 | - |
dc.description.abstract | Objectives: This study was designed to investigate the molecular epidemiology of Clostridioides difficile isolates in South Korea and to evaluate risk factors for rifaximin-non-susceptible C. difficile infection (CDI). Methods: A total of 413 patients with CDI from two sentinel hospitals in South Korea were enrolled in this study. Putative clinical risk factors for CDI were identified using digital medical records of the patients. Pathogen profiles, including antimicrobial susceptibility, toxin production and ribotype, were evaluated for each of the causative C. difficile isolates. Results: Of the 413 C. difficile isolates, 81 (19.6%) were shown to be rifaximin-non-susceptible, with the most common ribotypes being 018 (56.8%; 46/81), 017 (16.0%; 13/81) and 027 (6.2%; 5/81). Rifaximin-non-susceptible C. difficile isolates exhibited higher non-susceptibility rates to most of the other drugs tested in this study compared with rifaximin-susceptible isolates. Previous history of pulmonary tuberculosis and prior rifaximin treatment were shown to be associated with the occurrence of rifaximin-non-susceptible CDI compared with susceptible CDI. Conclusion: Non-susceptibility rates to rifaximin for the C. difficile isolates identified in this study were reasonably high with most of the resistant strains belonging to either ribotype 018 or 017. Widespread dissemination of these clones may be the result of antimicrobial selection pressure introduced by the widespread use of rifaximin. These results suggest that a sustainable surveillance programme for CDI and C. difficile resistance is needed in order to better control CDIs and to improve therapeutic efficacy. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Elsevier Ltd. | - |
dc.relation.isPartOf | JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Molecular epidemiology and clinical risk factors for rifaximin-non-susceptible Clostridioides difficile infection in South Korea: a prospective, multicentre, observational study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학교실) | - |
dc.contributor.googleauthor | Dokyun Kim | - |
dc.contributor.googleauthor | Young Ah Kim | - |
dc.contributor.googleauthor | Jung Lim Kim | - |
dc.contributor.googleauthor | Yoon Soo Park | - |
dc.contributor.googleauthor | Seok Hoon Jeong | - |
dc.contributor.googleauthor | Heejung Kim | - |
dc.identifier.doi | 10.1016/j.jgar.2021.07.009 | - |
dc.contributor.localId | A04891 | - |
dc.contributor.localId | A01219 | - |
dc.contributor.localId | A01598 | - |
dc.contributor.localId | A03619 | - |
dc.relation.journalcode | J01427 | - |
dc.identifier.eissn | 2213-7173 | - |
dc.identifier.pmid | 34320416 | - |
dc.subject.keyword | CDI | - |
dc.subject.keyword | Clostridioides difficile | - |
dc.subject.keyword | Epidemiology | - |
dc.subject.keyword | Ribotype | - |
dc.subject.keyword | Rifaximin | - |
dc.contributor.alternativeName | Kim, Dokyun | - |
dc.contributor.affiliatedAuthor | 김도균 | - |
dc.contributor.affiliatedAuthor | 김희정 | - |
dc.contributor.affiliatedAuthor | 박윤수 | - |
dc.contributor.affiliatedAuthor | 정석훈 | - |
dc.citation.volume | 27 | - |
dc.citation.startPage | 46 | - |
dc.citation.endPage | 50 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, Vol.27 : 46-50, 2021-07 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.