Cited 113 times in
Adipose tissue is a critical regulator of osteoarthritis
DC Field | Value | Language |
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dc.contributor.author | 최윤락 | - |
dc.date.accessioned | 2021-09-29T02:21:34Z | - |
dc.date.available | 2021-09-29T02:21:34Z | - |
dc.date.issued | 2021-01 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184848 | - |
dc.description.abstract | Osteoarthritis (OA), the leading cause of pain and disability worldwide, disproportionally affects individuals with obesity. The mechanisms by which obesity leads to the onset and progression of OA are unclear due to the complex interactions among the metabolic, biomechanical, and inflammatory factors that accompany increased adiposity. We used a murine preclinical model of lipodystrophy (LD) to examine the direct contribution of adipose tissue to OA. Knee joints of LD mice were protected from spontaneous or posttraumatic OA, on either a chow or high-fat diet, despite similar body weight and the presence of systemic inflammation. These findings indicate that adipose tissue itself plays a critical role in the pathophysiology of OA. Susceptibility to posttraumatic OA was reintroduced into LD mice using implantation of a small adipose tissue depot derived from wild-type animals or mouse embryonic fibroblasts that undergo spontaneous adipogenesis, implicating paracrine signaling from fat, rather than body weight, as a mediator of joint degeneration. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | National Academy of Sciences | - |
dc.relation.isPartOf | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adipose Tissue / metabolism* | - |
dc.subject.MESH | Adipose Tissue / physiopathology | - |
dc.subject.MESH | Adipose Tissue / transplantation | - |
dc.subject.MESH | Adiposity | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Body Weight | - |
dc.subject.MESH | Cartilage / pathology | - |
dc.subject.MESH | Cytokines / metabolism | - |
dc.subject.MESH | Diet, High-Fat / adverse effects | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Disease Susceptibility / complications | - |
dc.subject.MESH | Disease Susceptibility / metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fibroblasts / metabolism | - |
dc.subject.MESH | Hyperplasia / complications | - |
dc.subject.MESH | Inflammation / metabolism | - |
dc.subject.MESH | Lipodystrophy / diagnostic imaging | - |
dc.subject.MESH | Lipodystrophy / genetics | - |
dc.subject.MESH | Lipodystrophy / metabolism* | - |
dc.subject.MESH | Lipodystrophy / physiopathology | - |
dc.subject.MESH | Locomotion | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Muscle Strength | - |
dc.subject.MESH | Osteoarthritis, Knee / complications | - |
dc.subject.MESH | Osteoarthritis, Knee / diagnostic imaging | - |
dc.subject.MESH | Osteoarthritis, Knee / metabolism* | - |
dc.subject.MESH | Osteoarthritis, Knee / prevention & control | - |
dc.subject.MESH | Pain / complications | - |
dc.subject.MESH | Paracrine Communication / physiology | - |
dc.title | Adipose tissue is a critical regulator of osteoarthritis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Orthopedic Surgery (정형외과학교실) | - |
dc.contributor.googleauthor | Kelsey H Collins | - |
dc.contributor.googleauthor | Kristin L Lenz | - |
dc.contributor.googleauthor | Eleanor N Pollitt | - |
dc.contributor.googleauthor | Daniel Ferguson | - |
dc.contributor.googleauthor | Irina Hutson | - |
dc.contributor.googleauthor | Luke E Springer | - |
dc.contributor.googleauthor | Arin K Oestreich | - |
dc.contributor.googleauthor | Ruhang Tang | - |
dc.contributor.googleauthor | Yun-Rak Choi | - |
dc.contributor.googleauthor | Gretchen A Meyer | - |
dc.contributor.googleauthor | Steven L Teitelbaum | - |
dc.contributor.googleauthor | Christine T N Pham | - |
dc.contributor.googleauthor | Charles A Harris | - |
dc.contributor.googleauthor | Farshid Guilak | - |
dc.identifier.doi | 10.1073/pnas.2021096118 | - |
dc.contributor.localId | A04136 | - |
dc.relation.journalcode | J02550 | - |
dc.identifier.eissn | 1091-6490 | - |
dc.identifier.pmid | 33443201 | - |
dc.subject.keyword | adipocyte | - |
dc.subject.keyword | leptin | - |
dc.subject.keyword | muscle weakness | - |
dc.subject.keyword | subchondral bone sclerosis | - |
dc.subject.keyword | systemic inflammation | - |
dc.contributor.alternativeName | Choi, Yun Rak | - |
dc.contributor.affiliatedAuthor | 최윤락 | - |
dc.citation.volume | 118 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | e2021096118 | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol.118(1) : e2021096118, 2021-01 | - |
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