A Rare Case of Aggravated Hypercalcemia of Malignancy After Surgery

Abstract

Paraneoplastic syndromes are caused by ectopic hormone production in malignant tumors. Hypercalcemia of malignancy is the main manifestation of paraneoplastic syndromes and can lead to acute kidney injury, life-threatening arrhythmia, and cardiac arrest. Here, we present a 70-year-old Asian female with a probable diagnosis of advanced lung cancer with hypercalcemia of malignancy. She underwent surgery to treat a pathologic fracture of the humerus. In this case, hypercalcemia of malignancy was unexpectedly aggravated after surgery, and hypercalcemic complications led to a poor outcome for the patient.