Cited 5 times in
Association of body mass index with immune recovery, virological failure and cardiovascular disease risk among people living with HIV
DC Field | Value | Language |
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dc.contributor.author | 최준용 | - |
dc.date.accessioned | 2021-09-29T02:06:52Z | - |
dc.date.available | 2021-09-29T02:06:52Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.issn | 1464-2662 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184717 | - |
dc.description.abstract | Objectives: We conducted a longitudinal cohort analysis to evaluate the association of pre-treatment body mass index (BMI) with CD4 recovery, virological failure (VF) and cardiovascular risk disease (CVD) markers among people living with HIV (PLHIV). Methods: Participants who were enrolled between January 2003 and March 2019 in a regional Asia HIV cohort with weight and height measurements prior to antiretroviral therapy (ART) initiation were included. Factors associated with mean CD4 increase were analysed using repeated-measures linear regression. Time to first VF after 6 months on ART and time to first development of CVD risk markers were analysed using Cox regression models. Sensitivity analyses were done adjusting for Asian BMI thresholds. Results: Of 4993 PLHIV (66% male), 62% had pre-treatment BMI in the normal range (18.5-25.0 kg/m2 ), while 26%, 10% and 2% were underweight (< 18.5 kg/m2 ), overweight (25-30 kg/m2) and obese (> 30 kg/m2 ), respectively. Both higher baseline and time-updated BMI were associated with larger CD4 gains compared with normal BMI. After adjusting for Asian BMI thresholds, higher baseline BMIs of 23-27.5 and > 27.5 kg/m2 were associated with larger CD4 increases of 15.6 cells/µL [95% confidence interval (CI): 2.9-28.3] and 28.8 cells/µL (95% CI: 6.6-50.9), respectively, compared with normal BMI (18.5-23 kg/m2 ). PLHIV with BMIs of 25-30 and > 30 kg/m2 were 1.27 times (95% CI: 1.10-1.47) and 1.61 times (95% CI: 1.13-2.24) more likely to develop CVD risk factors. No relationship between pre-treatment BMI and VF was observed. Conclusions: High pre-treatment BMI was associated with better immune reconstitution and CVD risk factor development in an Asian PLHIV cohort. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Wiley | - |
dc.relation.isPartOf | HIV MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Association of body mass index with immune recovery, virological failure and cardiovascular disease risk among people living with HIV | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | W M Han | - |
dc.contributor.googleauthor | A Jiamsakul | - |
dc.contributor.googleauthor | J Jantarapakde | - |
dc.contributor.googleauthor | E Yunihastuti | - |
dc.contributor.googleauthor | J Y Choi | - |
dc.contributor.googleauthor | R Ditangco | - |
dc.contributor.googleauthor | R Chaiwarith | - |
dc.contributor.googleauthor | L P Sun | - |
dc.contributor.googleauthor | S Khusuwan | - |
dc.contributor.googleauthor | T P Merati | - |
dc.contributor.googleauthor | C D Do | - |
dc.contributor.googleauthor | I Azwa | - |
dc.contributor.googleauthor | M-P Lee | - |
dc.contributor.googleauthor | K Van Nguyen | - |
dc.contributor.googleauthor | Y-J Chan | - |
dc.contributor.googleauthor | S Kiertiburanakul | - |
dc.contributor.googleauthor | O T Ng | - |
dc.contributor.googleauthor | J Tanuma | - |
dc.contributor.googleauthor | S Pujari | - |
dc.contributor.googleauthor | F Zhang | - |
dc.contributor.googleauthor | Y M Gani | - |
dc.contributor.googleauthor | S Sangle | - |
dc.contributor.googleauthor | J Ross | - |
dc.contributor.googleauthor | N Kumarasamy | - |
dc.identifier.doi | 10.1111/hiv.13017 | - |
dc.contributor.localId | A04191 | - |
dc.relation.journalcode | J00998 | - |
dc.identifier.eissn | 1468-1293 | - |
dc.identifier.pmid | 33200864 | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/10.1111/hiv.13017 | - |
dc.subject.keyword | HIV | - |
dc.subject.keyword | body mass index | - |
dc.subject.keyword | cardiovascular risks | - |
dc.subject.keyword | immune recovery | - |
dc.subject.keyword | virological response | - |
dc.contributor.alternativeName | Choi, Jun Yong | - |
dc.contributor.affiliatedAuthor | 최준용 | - |
dc.citation.volume | 22 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 294 | - |
dc.citation.endPage | 306 | - |
dc.identifier.bibliographicCitation | HIV MEDICINE, Vol.22(4) : 294-306, 2021-04 | - |
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