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The Incidence and Effect of Cytomegalovirus Disease on Mortality in Transplant Recipients and General Population: Real-world Nationwide Cohort Data

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dc.contributor.author이경화-
dc.contributor.author한상훈-
dc.contributor.author한상훈-
dc.contributor.author라연주-
dc.contributor.author권다은-
dc.date.accessioned2021-09-29T02:02:10Z-
dc.date.available2021-09-29T02:02:10Z-
dc.date.issued2021-07-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184677-
dc.description.abstractBackground: In addition to the conventional opportunistic infections in solid organ transplantation (SOT) and hematopoietic stem cell transplantation (HSCT) recipients, cytomegalovirus (CMV) infection is associated with various chronic inflammatory diseases or poor outcomes in non-immunocompromised critically ill patients. To evaluate the burden or outcome of CMV replication in non-transplant individuals, we compared the incidence rates (IRs) for CMV disease and all-cause mortality between SOT recipients, HSCT recipients, and non-transplant population. Methods: The SOT (N=16,368) and HSCT (N=10,206) cohorts between 2010 and 2015 were established using the WHO ICD-10 from the whole population-based large database of the Health Insurance Review & Assessment Service (HIRA). CMV cases, defined as symptomatic disease with isolation of virus, DNA, pp65 antigen, and pathology except CMV syndrome, were extracted with the unique codes for relief of medical costs of HIRA in the same dataset. Cox's proportional hazard regression analyses and log-rank test in the Kaplan-Meier curves were performed to compare all-cause mortality between the three groups. Results: The CMV IRs adjusted by age and sex were significantly higher in the SOT (adjusted IR [95% confidence intervals], 33.1 [28.8-38.0] per 1,000 person-years) and HSCT recipients (5.1 [4.6-6.1] per 1,000 person-years) than in the whole population (0.58 [0.49-0.67] per 100,000 person-years). However, SOT recipients with CMV (18/283, 6.4%) had significantly lower all-cause mortality than non-transplant individuals with CMV (207/1,258, 16.5%) (adjusted hazard ratio [95% CI], 0.42 [0.25-0.67], log-rank P < 0.001). Conclusion: These data suggest that CMV disease in patients without transplants is associated with poor outcomes.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherIvyspring International Publisher-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF MEDICAL SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleThe Incidence and Effect of Cytomegalovirus Disease on Mortality in Transplant Recipients and General Population: Real-world Nationwide Cohort Data-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorSang Hoon Han-
dc.contributor.googleauthorSeul Gi Yoo-
dc.contributor.googleauthorKyung Do Han-
dc.contributor.googleauthorYeonju La-
dc.contributor.googleauthorDa Eun Kwon-
dc.contributor.googleauthorKyoung Hwa Lee-
dc.identifier.doi10.7150/ijms.62621-
dc.contributor.localIdA04620-
dc.contributor.localIdA04286-
dc.contributor.localIdA04286-
dc.relation.journalcodeJ02917-
dc.identifier.eissn1449-1907-
dc.identifier.pmid34400903-
dc.subject.keywordCytomegalovirus-
dc.subject.keywordDisease-
dc.subject.keywordHematopoietic stem cell transplantation-
dc.subject.keywordIncidence-
dc.subject.keywordMortality-
dc.subject.keywordPopulation-
dc.subject.keywordSolid organ transplantation-
dc.contributor.alternativeNameLee, Kyoung Hwa-
dc.contributor.affiliatedAuthor이경화-
dc.contributor.affiliatedAuthor한상훈-
dc.contributor.affiliatedAuthor한상훈-
dc.citation.volume18-
dc.citation.number14-
dc.citation.startPage3333-
dc.citation.endPage3341-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF MEDICAL SCIENCES, Vol.18(14) : 3333-3341, 2021-07-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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