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Human Adipose Mesenchymal Stem Cell-Derived Exosomes: A Key Player in Wound Healing

Authors
 June Seok Heo  ;  Sinyoung Kim  ;  Chae Eun Yang  ;  Youjeong Choi  ;  Seung Yong Song  ;  Hyun Ok Kim 
Citation
 TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Vol.18(4) : 537-548, 2021-08 
Journal Title
TISSUE ENGINEERING AND REGENERATIVE MEDICINE
ISSN
 1738-2696 
Issue Date
2021-08
Keywords
Adipose-derived stem cells ; Exosomes ; Inflammation ; Wound healing
Abstract
Background: Human adipose-derived mesenchymal stem cells (AMSCs) are an attractive resource for wound healing because their regenerative capacity improves injury repair. Recently, stem cell-derived exosomes have been shown to play a positive role in stem cell-based therapies. However, the effects of exosomes derived from AMSCs (AEXOs) on wound healing are unclear. In this study, we aimed to examine the role of AEXOs in attenuating inflammation and explore their effects in normal wound healing.

Methods: We isolated exosomes from AMSCs and established a cellular model of inflammation by treatment with the inflammatory cytokines, interferon gamma and tumor necrosis factor alpha, to determine whether AEXOs can inhibit inflammation. We examined the wound healing effects of AEXOs in in vitro wound healing models and performed a miRNA array to understand the role of AEXOs in inflammation and wound healing.

Results: A significant difference was observed in wound closure and the expression of anti-inflammatory and wound-healing-related factors between control and AEXO-treated cells.

Conclusion: Our results showed that besides alleviating the inflammation response, AEXOs also promote wound healing. Thus, AEXOs represent a novel, stem-cell-based, therapeutic strategy for wound healing.
Full Text
https://link.springer.com/article/10.1007/s13770-020-00316-x
DOI
10.1007/s13770-020-00316-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sin Young(김신영) ORCID logo https://orcid.org/0000-0002-2609-8945
Kim, Hyun Ok(김현옥) ORCID logo https://orcid.org/0000-0002-4964-1963
Song, Seung Yong(송승용) ORCID logo https://orcid.org/0000-0002-3145-7463
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184651
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