Cited 3 times in
Administration of Low-Dose Dexmedetomidine Did Not Affect Acute Inflammatory Response after Cytoreductive Surgery Combined with Hyperthermic Intraperitoneal Chemotherapy: A Double-Blind Randomized Controlled Trial
DC Field | Value | Language |
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dc.contributor.author | 김나영 | - |
dc.contributor.author | 김명화 | - |
dc.contributor.author | 문지애 | - |
dc.contributor.author | 유영철 | - |
dc.contributor.author | 전소영 | - |
dc.date.accessioned | 2021-09-29T01:57:31Z | - |
dc.date.available | 2021-09-29T01:57:31Z | - |
dc.date.issued | 2021-07 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184633 | - |
dc.description.abstract | During cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC), attenuation of inflammatory responses that increase susceptibility to postoperative complications, morbidity, and mortality is important. We aimed to evaluate whether intraoperative dexmedetomidine infusion impacted inflammatory response in patients undergoing CRS with HIPEC. Fifty-six patients scheduled for CRS with HIPEC were randomly assigned to the control (n = 28) and dexmedetomidine (n = 28) groups. The primary endpoint was the effect of dexmedetomidine on the interleukin-6 (IL-6) level measured at pre-operation (Pre-OP), before HIPEC initiation (Pre-HIPEC), immediately after HIPEC; after the end of the operation; and on postoperative day (POD) 1. In both groups, the IL-6 levels from Pre-HIPEC until POD 1 and the C-reactive protein (CRP) levels on PODs 1, 2, and 3 were significantly higher than the Pre-OP values (all Bonferroni corrected, p < 0.001). However, total differences in IL-6 and CRP levels, based on the mean area under the curve, were not detected between the two groups. The continuous intraoperative infusion of dexmedetomidine (0.4 μg/kg/h) in patients undergoing CRS with HIPEC did not significantly lower the inflammatory indices. Further dose investigative studies are needed to find the dexmedetomidine dose that provides anti-inflammatory and sympatholytic effects during HIPEC. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | MDPI AG | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Administration of Low-Dose Dexmedetomidine Did Not Affect Acute Inflammatory Response after Cytoreductive Surgery Combined with Hyperthermic Intraperitoneal Chemotherapy: A Double-Blind Randomized Controlled Trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) | - |
dc.contributor.googleauthor | Jiae Moon | - |
dc.contributor.googleauthor | Young Chul Yoo | - |
dc.contributor.googleauthor | Myoung Hwa Kim | - |
dc.contributor.googleauthor | Soyoung Jeon | - |
dc.contributor.googleauthor | Hye Ji Joo | - |
dc.contributor.googleauthor | Duk-Hee Chun | - |
dc.contributor.googleauthor | Na Young Kim | - |
dc.identifier.doi | 10.3390/jcm10143145 | - |
dc.contributor.localId | A00348 | - |
dc.contributor.localId | A00429 | - |
dc.contributor.localId | A06073 | - |
dc.contributor.localId | A02484 | - |
dc.relation.journalcode | J03556 | - |
dc.identifier.eissn | 2077-0383 | - |
dc.identifier.pmid | 34300310 | - |
dc.subject.keyword | cytoreductive surgery | - |
dc.subject.keyword | dexmedetomidine | - |
dc.subject.keyword | hyperthermic intraperitoneal chemotherapy | - |
dc.subject.keyword | inflammatory response | - |
dc.subject.keyword | interleukin-6 | - |
dc.contributor.alternativeName | Kim, Na Young | - |
dc.contributor.affiliatedAuthor | 김나영 | - |
dc.contributor.affiliatedAuthor | 김명화 | - |
dc.contributor.affiliatedAuthor | 문지애 | - |
dc.contributor.affiliatedAuthor | 유영철 | - |
dc.citation.volume | 10 | - |
dc.citation.number | 14 | - |
dc.citation.startPage | 3145 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, Vol.10(14) : 3145, 2021-07 | - |
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