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Predictive Ability of Serum IL-27 Level for Assessing Activity of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

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dc.contributor.author박용범-
dc.contributor.author송정식-
dc.contributor.author안성수-
dc.contributor.author이상원-
dc.contributor.author이은주-
dc.contributor.author표정윤-
dc.date.accessioned2021-09-29T01:52:56Z-
dc.date.available2021-09-29T01:52:56Z-
dc.date.issued2021-07-
dc.identifier.issn0962-9351-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184595-
dc.description.abstractSerum interleukin- (IL-) 27 level has been reported to increase in patients with several autoimmune diseases; however, its significance in patients with antineutrophil cytoplasmic antibody- (ANCA-) associated vasculitis (AAV) is unknown. In this study, we investigated the associations between serum IL-27, laboratory features, and activity of AAV and evaluate the predictive ability of serum IL-27 level for disease activity. This study included 77 AAV patients, and we collected clinical and laboratory data at blood sampling. Inflammation-related variables included white blood cell, neutrophil, lymphocyte and platelet counts, serum albumin, erythrocyte sedimentation rate, and C-reactive protein levels. Serum IL-27 and IL-18 levels were measured from stored sera using Human Magnetic Luminex® assay. High disease activity of AAV was defined as the highest tertile of Birmingham vasculitis activity score (BVAS) (≥11). The mean age of the enrolled patients was 59.9 years, and 38 (49.4%) were diagnosed as microscopic polyangiitis. In the multivariable analysis, serum albumin (β = -0.419) and serum IL-27 level (β = 0.221) were significantly associated with BVAS. Furthermore, patients with renal manifestation exhibited higher serum IL-27 (mean 308.7 pg/mL vs. 105.8 pg/mL) and IL-18 levels (mean 376.7 pg/mL vs. 270.4 pg/mL) than those without. On applying the optimal cut-off of serum IL-27 level for predicting high activity, AAV patients with serum IL - 27 level ≥ 300.8 pg/mL had a significantly higher risk for having high disease activity than those with serum IL - 27 level < 300.8 pg/mL (relative risk 3.380, 95% confidence interval 1.223, 9.345, P = 0.016). These results suggest that serum IL-27 level is associated with the cross-sectional activity and the presence of renal manifestation and could be used to predict high disease activity in patients with AAV.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherHindawi Pub. Corp.-
dc.relation.isPartOfMEDIATORS OF INFLAMMATION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePredictive Ability of Serum IL-27 Level for Assessing Activity of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorTaejun Yoon-
dc.contributor.googleauthorSung Soo Ahn-
dc.contributor.googleauthorJung Yoo Pyo-
dc.contributor.googleauthorLucy Eunju Lee-
dc.contributor.googleauthorJason Jungsik Song-
dc.contributor.googleauthorYong-Beom Park-
dc.contributor.googleauthorSang-Won Lee-
dc.identifier.doi10.1155/2021/6668884-
dc.contributor.localIdA01579-
dc.contributor.localIdA02057-
dc.contributor.localIdA02233-
dc.contributor.localIdA02824-
dc.contributor.localIdA05935-
dc.contributor.localIdA04244-
dc.relation.journalcodeJ02194-
dc.identifier.eissn1466-1861-
dc.identifier.pmid34335091-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.affiliatedAuthor박용범-
dc.contributor.affiliatedAuthor송정식-
dc.contributor.affiliatedAuthor안성수-
dc.contributor.affiliatedAuthor이상원-
dc.contributor.affiliatedAuthor이은주-
dc.contributor.affiliatedAuthor표정윤-
dc.citation.volume2021-
dc.citation.startPage6668884-
dc.identifier.bibliographicCitationMEDIATORS OF INFLAMMATION, Vol.2021 : 6668884, 2021-07-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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