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Late-Stage 18 F/ 19 F Isotopic Exchange for the Synthesis of 18 F-Labeled Sulfamoyl Fluorides

Authors
 Min Ho Jeon  ;  Young-Do Kwon  ;  Min Pyeong Kim  ;  Gianluca Bartolini Torres  ;  Jeong Kon Seo  ;  Jeongmin Son  ;  Young Hoon Ryu  ;  Sung You Hong  ;  Joong-Hyun Chun 
Citation
 ORGANIC LETTERS, Vol.23(7) : 2766-2771, 2021-04 
Journal Title
ORGANIC LETTERS
ISSN
 1523-7060 
Issue Date
2021-04
Abstract
Synthesis of sulfamoyl [18F]fluorides has been a challenging topic owing to the inefficient nucleophilic radiofluorination of sulfamoyl derivatives. Herein, we report an 18F/19F isotopic exchange approach to synthesize various sulfamoyl [18F]fluorides, otherwise inaccessible via direct synthesis from amines, with high radiochemical yields up to 97% (30 examples). This late-stage labeling protocol offers an efficient route to yield functionalized molecules by diversifying the chemical library possessing sulfamoyl functionalities through nucleophilic 18F incorporation within nitrogen-containing sulfur(VI) frameworks.
Full Text
https://pubs.acs.org/doi/10.1021/acs.orglett.1c00671
DOI
10.1021/acs.orglett.1c00671
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Chun, Joong-Hyun(전중현) ORCID logo https://orcid.org/0000-0002-9665-7829
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184568
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