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Cited 3 times in

Genetic Analysis and Operative Outcomes in Patients with Oncogene-Driven Advanced NSCLC Treated with Cytoreductive Surgery as a Component of Local Consolidative Therapy

DC Field Value Language
dc.contributor.author김혜련-
dc.contributor.author박병조-
dc.contributor.author박성용-
dc.contributor.author심효섭-
dc.contributor.author이상훈-
dc.contributor.author이진구-
dc.contributor.author이창영-
dc.contributor.author홍민희-
dc.date.accessioned2021-09-29T01:44:50Z-
dc.date.available2021-09-29T01:44:50Z-
dc.date.issued2021-06-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184527-
dc.description.abstractMost patients with oncogene-driven advanced non-small cell lung cancer (NSCLC) demonstrate recurrence because of the developing targeted therapy resistance. In this retrospective study, we assessed the efficacy of surgical local consolidative treatment by analyzing the operative outcomes and genetic data in 44 patients who underwent pulmonary resection for stage IIIB/C-IV NSCLC after targeted therapy. The initial mutations were in the EGFR (n = 32), ALK (n = 11), and ROS1 (n = 1) genes. The median interval from the initiation of tyrosine kinase inhibitor (TKI) therapy immediately before the surgery to the actual operation was 9.8 months. Operative mortality was absent. Four patients showed complete remission. The median follow-up period after TKI therapy initiation was 23.1 months. The Kaplan-Meier survival analysis showed that the 2-year failure-free survival and overall survival rates from the initiation of TKI were 70.8% and 95.0%, respectively. During the follow-up period, two patients died and 15 suffered from disease progression. Among the 32 patients with EGFR mutations, 12 showed additional mutations, and targeted agents were replaced in nine patients after the operation. We conclude that pulmonary resection for advanced NSCLC after targeted therapy is feasible, and the surgical specimens could be used for planning further targeted therapy.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfCANCERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleGenetic Analysis and Operative Outcomes in Patients with Oncogene-Driven Advanced NSCLC Treated with Cytoreductive Surgery as a Component of Local Consolidative Therapy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorByung Jo Park-
dc.contributor.googleauthorHyo Sup Shim-
dc.contributor.googleauthorChang Young Lee-
dc.contributor.googleauthorJin Gu Lee-
dc.contributor.googleauthorHye Ryun Kim-
dc.contributor.googleauthorSang Hoon Lee-
dc.contributor.googleauthorMin Hee Hong-
dc.contributor.googleauthorSeong Yong Park-
dc.identifier.doi10.3390/cancers13112549-
dc.contributor.localIdA01166-
dc.contributor.localIdA06090-
dc.contributor.localIdA01508-
dc.contributor.localIdA02219-
dc.contributor.localIdA02836-
dc.contributor.localIdA03225-
dc.contributor.localIdA03245-
dc.contributor.localIdA04393-
dc.relation.journalcodeJ03449-
dc.identifier.eissn2072-6694-
dc.identifier.pmid34067376-
dc.subject.keywordadvanced lung cancer-
dc.subject.keywordcytoreductive surgery-
dc.subject.keywordlocal consolidation-
dc.subject.keywordoligometastasis-
dc.subject.keywordoncogenic-driven-
dc.contributor.alternativeNameKim, Hye Ryun-
dc.contributor.affiliatedAuthor김혜련-
dc.contributor.affiliatedAuthor박병조-
dc.contributor.affiliatedAuthor박성용-
dc.contributor.affiliatedAuthor심효섭-
dc.contributor.affiliatedAuthor이상훈-
dc.contributor.affiliatedAuthor이진구-
dc.contributor.affiliatedAuthor이창영-
dc.contributor.affiliatedAuthor홍민희-
dc.citation.volume13-
dc.citation.number11-
dc.citation.startPage2549-
dc.identifier.bibliographicCitationCANCERS, Vol.13(11) : 2549, 2021-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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