Cited 3 times in
Genomic landscape of extraordinary responses in metastatic breast cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 구자승 | - |
dc.contributor.author | 김건민 | - |
dc.contributor.author | 김민환 | - |
dc.contributor.author | 김상우 | - |
dc.contributor.author | 김승일 | - |
dc.contributor.author | 김지예 | - |
dc.contributor.author | 김지형 | - |
dc.contributor.author | 박병우 | - |
dc.contributor.author | 박세호 | - |
dc.contributor.author | 박형석 | - |
dc.contributor.author | 백순명 | - |
dc.contributor.author | 손주혁 | - |
dc.contributor.author | 임선민 | - |
dc.contributor.author | 전민경 | - |
dc.contributor.author | 조영업 | - |
dc.date.accessioned | 2021-09-29T01:37:02Z | - |
dc.date.available | 2021-09-29T01:37:02Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184461 | - |
dc.description.abstract | Extreme responders to anticancer therapy are rare among advanced breast cancer patients. Researchers, however, have yet to investigate treatment responses therein on the whole exome level. We performed whole exome analysis to characterize the genomic landscape of extreme responders among metastatic breast cancer patients. Clinical samples were obtained from breast cancer patients who showed exceptional responses to anti-HER2 therapy or hormonal therapy and from those who did not. Matched breast tumor tissue (somatic DNA) and blood samples (germline DNA) were collected from a total of 30 responders and 15 non-responders. Whole exome sequencing using Illumina HiSeq2500 was performed for all 45 patients (90 samples). Somatic single nucleotide variants (SNVs), indels, and copy number variants (CNVs) were identified for the genomes of each patient. Group-specific somatic variants and mutational burden were statistically analyzed. Sequencing of cancer exomes for all patients revealed 1839 somatic SNVs (1661 missense, 120 nonsense, 43 splice-site, 15 start/stop-lost) and 368 insertions/deletions (273 frameshift, 95 in-frame), with a median of 0.7 mutations per megabase (range, 0.08 to 4.2 mutations per megabase). Responders harbored a significantly lower nonsynonymous mutational burden (median, 26 vs. 59, P = 0.02) and fewer CNVs (median 13.6 vs. 97.7, P = 0.05) than non-responders. Multivariate analyses of factors influencing progression-free survival showed that a high mutational burden and visceral metastases were significantly related with disease progression. Extreme responders to treatment for metastatic breast cancer are characterized by fewer nonsynonymous mutations and CNVs. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group UK | - |
dc.relation.isPartOf | COMMUNICATIONS BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Genomic landscape of extraordinary responses in metastatic breast cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Sun Min Lim | - |
dc.contributor.googleauthor | Eunyoung Kim | - |
dc.contributor.googleauthor | Kyung Hae Jung | - |
dc.contributor.googleauthor | Sora Kim | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.contributor.googleauthor | Seung Il Kim | - |
dc.contributor.googleauthor | Seho Park | - |
dc.contributor.googleauthor | Hyung Seok Park | - |
dc.contributor.googleauthor | Byoung Woo Park | - |
dc.contributor.googleauthor | Young Up Cho | - |
dc.contributor.googleauthor | Ji Ye Kim | - |
dc.contributor.googleauthor | Soonmyung Paik | - |
dc.contributor.googleauthor | Nak-Jung Kwon | - |
dc.contributor.googleauthor | Gun Min Kim | - |
dc.contributor.googleauthor | Ji Hyoung Kim | - |
dc.contributor.googleauthor | Min Hwan Kim | - |
dc.contributor.googleauthor | Min Kyung Jeon | - |
dc.contributor.googleauthor | Sangwoo Kim | - |
dc.contributor.googleauthor | Joohyuk Sohn | - |
dc.identifier.doi | 10.1038/s42003-021-01973-x | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A00287 | - |
dc.contributor.localId | A00482 | - |
dc.contributor.localId | A00524 | - |
dc.contributor.localId | A00658 | - |
dc.contributor.localId | A00984 | - |
dc.contributor.localId | A00999 | - |
dc.contributor.localId | A01475 | - |
dc.contributor.localId | A01524 | - |
dc.contributor.localId | A01753 | - |
dc.contributor.localId | A01823 | - |
dc.contributor.localId | A01995 | - |
dc.contributor.localId | A03369 | - |
dc.contributor.localId | A05978 | - |
dc.contributor.localId | A05420 | - |
dc.relation.journalcode | J03836 | - |
dc.identifier.eissn | 2399-3642 | - |
dc.identifier.pmid | 33837242 | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.contributor.affiliatedAuthor | 김건민 | - |
dc.contributor.affiliatedAuthor | 김민환 | - |
dc.contributor.affiliatedAuthor | 김상우 | - |
dc.contributor.affiliatedAuthor | 김승일 | - |
dc.contributor.affiliatedAuthor | 김지예 | - |
dc.contributor.affiliatedAuthor | 김지형 | - |
dc.contributor.affiliatedAuthor | 박병우 | - |
dc.contributor.affiliatedAuthor | 박세호 | - |
dc.contributor.affiliatedAuthor | 박형석 | - |
dc.contributor.affiliatedAuthor | 백순명 | - |
dc.contributor.affiliatedAuthor | 손주혁 | - |
dc.contributor.affiliatedAuthor | 임선민 | - |
dc.contributor.affiliatedAuthor | 전민경 | - |
dc.contributor.affiliatedAuthor | 조영업 | - |
dc.citation.volume | 4 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 449 | - |
dc.identifier.bibliographicCitation | COMMUNICATIONS BIOLOGY, Vol.4(1) : 449, 2021-04 | - |
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