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Clinical Characteristics of Long-Term Survivors After Sorafenib Treatment for Unresectable Hepatocellular Carcinoma: A Korean National Multicenter Retrospective Cohort Study

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dc.contributor.author김도영-
dc.contributor.author이혜원-
dc.date.accessioned2021-09-29T01:34:09Z-
dc.date.available2021-09-29T01:34:09Z-
dc.date.issued2021-06-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184432-
dc.description.abstractBackground/aim: Sorafenib is the first systemic therapy for the treatment of advanced-stage hepatocellular carcinoma (HCC) and progressive HCC after locoregional therapy. The aim of this study was to evaluate the prognostic factors of long-term survivors after sorafenib treatment. Methods: This multicenter, retrospective, cohort study included 1,566 unresectable HCC patients who received sorafenib treatment between 2007 and 2014 in nine tertiary centers in Korea. The patients were classified into a long-term survivor group (survival more than two years, n = 257) or a control group (n = 1309). The primary outcomes were the prognostic factors affecting long-term survival. Secondary endpoints included time-to-progression and other safety profiles. Results: The patients were predominantly men (83.8%) with chronic hepatitis B (77.3%) and Barcelona clinic of liver cancer-stage C (BCLC-C) (78.3%). The median overall survival was 9.0 months. After treatment, eight patients (0.4%) achieved complete response and 139 patients (8.8%) achieved partial response according to the mRECIST criteria. The prognostic factors predicting long-term survival were metformin use (adjusted hazard ratio [aHR] = 3.464; P < 0.001), hand-foot skin reaction (aHR = 1.688; P = 0.003), and concomitant treatment with chemoembolization or radiotherapy (aHR = 2.766; P < 0.001). Poor prognostic factors of long-term survival were a Child-Pugh score of B (HR = 0.422; P < 0.001), the presence of extrahepatic metastasis (HR = 0.639; P = 0.005), main portal vein invasion (HR = 0.502; P = 0.001), and elevated alpha-fetoprotein (>1,000 ng/mL; HR = 0.361; P < 0.001). Conclusion: This large, multicenter, retrospective study showed an objective response rate of 9.1% and a proportion of long-term survivors of 16.4% in Korean patients. The prognostic factors derived in our study can be used in clinical practice during sorafenib treatment.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherDove Press-
dc.relation.isPartOfJOURNAL OF HEPATOCELLULAR CARCINOMA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleClinical Characteristics of Long-Term Survivors After Sorafenib Treatment for Unresectable Hepatocellular Carcinoma: A Korean National Multicenter Retrospective Cohort Study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorYoung Youn Cho-
dc.contributor.googleauthorSu Jong Yu-
dc.contributor.googleauthorHye Won Lee-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorWonseok Kang-
dc.contributor.googleauthorYong-Han Paik-
dc.contributor.googleauthorPil Soo Sung-
dc.contributor.googleauthorSi Hyun Bae-
dc.contributor.googleauthorSu Cheol Park-
dc.contributor.googleauthorYoung Seok Doh-
dc.contributor.googleauthorKang Mo Kim-
dc.contributor.googleauthorEun Sun Jang-
dc.contributor.googleauthorIn Hee Kim-
dc.contributor.googleauthorWon Kim-
dc.contributor.googleauthorYoon Jun Kim-
dc.identifier.doi10.2147/JHC.S304439-
dc.contributor.localIdA00385-
dc.contributor.localIdA03318-
dc.relation.journalcodeJ03970-
dc.identifier.eissn2253-5969-
dc.identifier.pmid34169044-
dc.subject.keywordhepatocellular carcinoma-
dc.subject.keywordprognosis-
dc.subject.keywordsorafenib-
dc.subject.keywordsurvival-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.affiliatedAuthor김도영-
dc.contributor.affiliatedAuthor이혜원-
dc.citation.volume8-
dc.citation.startPage613-
dc.citation.endPage623-
dc.identifier.bibliographicCitationJOURNAL OF HEPATOCELLULAR CARCINOMA, Vol.8 : 613-623, 2021-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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