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Independent Risk Factors for Hepatocellular Carcinoma Recurrence after Direct-Acting Antiviral Therapy in Patients with Chronic Hepatitis C

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dc.contributor.author김도영-
dc.contributor.author이혜원-
dc.date.accessioned2021-09-29T01:33:37Z-
dc.date.available2021-09-29T01:33:37Z-
dc.date.issued2021-05-
dc.identifier.issn1976-2283-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184428-
dc.description.abstractBackground/aims: This study was performed to evaluate the efficacy of direct-acting antivirals (DAAs) in Korean patients with hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) and to investigate the risk factors associated with HCC recurrence. Methods: A total of 100 patients with HCV-related HCC, who were treated with DAAs between May 2015 and December 2016, were recruited from seven university hospitals in Korea. Claim data of 526 patients with HCC obtained from the Health Insurance Review and Assessment Service in South Korea were used for external validation of the results. Results: Among the 100 patients, 88% achieved a sustained virological response (SVR) 12 weeks after the end of DAA therapy (SVR12), and 37% experienced HCC recurrence after DAA therapy. Short last HCC treatment durability (<12 months) before DAA commencement was independently associated with HCC recurrence (hazard ratio [HR], 2.89; p=0.011). In the nationwide validation cohort, 20.3% of the patients experienced HCC recurrence. The last HCC treatment with a noncurative method, a short last HCC treatment durability (<12 months), and a longer total duration of HCC treatment (≥18 months) were independently related with HCC recurrence (HR 3.73, p<0.001; HR 3.34, p<0.001; and HR 1.74, p=0.006; respectively). Conclusions: DAA therapy showed an acceptable SVR12 rate in patients with HCV-related HCC. Short last HCC treatment durability (<12 months) was associated with HCC recurrence after DAA therapy. This finding suggests that the last HCC treatment durability is an important predictor of HCC recurrence after DAA therapy.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherEditorial Office of Gut and Liver-
dc.relation.isPartOfGUT AND LIVER-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleIndependent Risk Factors for Hepatocellular Carcinoma Recurrence after Direct-Acting Antiviral Therapy in Patients with Chronic Hepatitis C-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorYoung-Hwan Ahn-
dc.contributor.googleauthorHeirim Lee-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorHye Won Lee-
dc.contributor.googleauthorSu Jong Yu-
dc.contributor.googleauthorYoung Youn Cho-
dc.contributor.googleauthorJeong Won Jang-
dc.contributor.googleauthorByoung Kuk Jang-
dc.contributor.googleauthorChang Wook Kim-
dc.contributor.googleauthorHee Yeon Kim-
dc.contributor.googleauthorHana Park-
dc.contributor.googleauthorHyo Jung Cho-
dc.contributor.googleauthorBumhee Park-
dc.contributor.googleauthorSoon Sun Kim-
dc.contributor.googleauthorJae Youn Cheong-
dc.identifier.doi10.5009/gnl20151-
dc.contributor.localIdA00385-
dc.contributor.localIdA03318-
dc.relation.journalcodeJ00954-
dc.identifier.eissn2005-1212-
dc.identifier.pmid32893194-
dc.subject.keywordAntiviral agents-
dc.subject.keywordCarcinoma-
dc.subject.keywordHepatitis C-
dc.subject.keywordRecurrence-
dc.subject.keywordRisk factors-
dc.subject.keywordchronic-
dc.subject.keywordhepatocellular-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.affiliatedAuthor김도영-
dc.contributor.affiliatedAuthor이혜원-
dc.citation.volume15-
dc.citation.number3-
dc.citation.startPage410-
dc.citation.endPage419-
dc.identifier.bibliographicCitationGUT AND LIVER, Vol.15(3) : 410-419, 2021-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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