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Glycolysis on F-18 FDG PET/CT Is Superior to Amino Acid Metabolism on C-11 Methionine PET/CT in Identifying Advanced Renal Cell Carcinoma at Staging

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dc.contributor.author김동우-
dc.contributor.author김현정-
dc.contributor.author박지수-
dc.contributor.author윤미진-
dc.contributor.author이승환-
dc.contributor.author최영득-
dc.contributor.author한웅규-
dc.contributor.author함원식-
dc.contributor.author김현정-
dc.contributor.author박지수-
dc.contributor.author윤미진-
dc.contributor.author이승환-
dc.contributor.author최영득-
dc.contributor.author한웅규-
dc.contributor.author함원식-
dc.date.accessioned2021-09-29T01:32:18Z-
dc.date.available2021-09-29T01:32:18Z-
dc.date.issued2021-05-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184419-
dc.description.abstractWe evaluated the value of F-18 fluorodeoxyglucose (FDG) and C-11 methionine positron emission tomography/computed tomography (PET/CT) to predict high-Fuhrman grade and advanced-stage tumours in patients with renal cell carcinoma (RCC). Forty patients with RCC underwent F-18 FDG and C-11 methionine PET/CT between September 2016 and September 2018. They were classified into limited (stages I and II, n = 15) or advanced stages (stages III and IV, n = 25) according to pathological staging. Logistic regressions were used to predict the advanced stage using various parameters, including maximum standardised uptake value (SUVmax) and metabolic tumour volume (MTV). Receiver operating characteristic analyses were performed to predict high-grade tumours (Fuhrman 3 and 4). On univariate analysis, tumour size, SUVmax and MTV of F-18 FDG and C-11 methionine, and Fuhrman grades were significant predictors for the advanced stage. On multivariate analysis, F-18 FDG MTV > 21.3 cm3 was the most significant predictor (p < 0.001). The area under the curve for predicting high-grade tumours was 0.830 for F-18 FDG (p < 0.001) and 0.726 for C-11 methionine PET/CT (p = 0.014). In conclusion, glycolysis on F-18 FDG PET/CT and amino acid metabolism on C-11 methionine PET/CT were variable but increased in high-grade RCCs. Increased MTV on F-18 FDG PET/CT is a powerful predictor of advanced-stage tumours.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfCANCERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleGlycolysis on F-18 FDG PET/CT Is Superior to Amino Acid Metabolism on C-11 Methionine PET/CT in Identifying Advanced Renal Cell Carcinoma at Staging-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Nuclear Medicine (핵의학교실)-
dc.contributor.googleauthorSuk-Hyun Lee-
dc.contributor.googleauthorJee-Soo Park-
dc.contributor.googleauthorHyunjeong Kim-
dc.contributor.googleauthorDongwoo Kim-
dc.contributor.googleauthorSeung-Hwan Lee-
dc.contributor.googleauthorWon-Sik Ham-
dc.contributor.googleauthorWoong-Kyu Han-
dc.contributor.googleauthorYoung-Deuk Choi-
dc.contributor.googleauthorMijin Yun-
dc.identifier.doi10.3390/cancers13102381-
dc.contributor.localIdA05304-
dc.contributor.localIdA01129-
dc.contributor.localIdA05336-
dc.contributor.localIdA02550-
dc.contributor.localIdA02938-
dc.contributor.localIdA04111-
dc.contributor.localIdA04308-
dc.contributor.localIdA04337-
dc.contributor.localIdA01129-
dc.contributor.localIdA05336-
dc.contributor.localIdA02550-
dc.contributor.localIdA02938-
dc.contributor.localIdA04111-
dc.contributor.localIdA04308-
dc.contributor.localIdA04337-
dc.relation.journalcodeJ03449-
dc.identifier.eissn2072-6694-
dc.identifier.pmid34069168-
dc.subject.keywordC-11 methionine-
dc.subject.keywordF-18 fluorodeoxyglucose-
dc.subject.keywordpositron emission tomography-
dc.subject.keywordrenal cell carcinoma-
dc.contributor.alternativeNameKim, Dongwoo-
dc.contributor.affiliatedAuthor김동우-
dc.contributor.affiliatedAuthor김현정-
dc.contributor.affiliatedAuthor박지수-
dc.contributor.affiliatedAuthor윤미진-
dc.contributor.affiliatedAuthor이승환-
dc.contributor.affiliatedAuthor최영득-
dc.contributor.affiliatedAuthor한웅규-
dc.contributor.affiliatedAuthor함원식-
dc.contributor.affiliatedAuthor김현정-
dc.contributor.affiliatedAuthor박지수-
dc.contributor.affiliatedAuthor윤미진-
dc.contributor.affiliatedAuthor이승환-
dc.contributor.affiliatedAuthor최영득-
dc.contributor.affiliatedAuthor한웅규-
dc.contributor.affiliatedAuthor함원식-
dc.citation.volume13-
dc.citation.number10-
dc.citation.startPage2381-
dc.identifier.bibliographicCitationCANCERS, Vol.13(10) : 2381, 2021-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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