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Prognostic value of lower bone mineral density in predicting adverse cardiovascular disease in Asian women

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dc.contributor.author김경민-
dc.date.accessioned2021-09-29T01:29:39Z-
dc.date.available2021-09-29T01:29:39Z-
dc.date.issued2021-07-
dc.identifier.issn1355-6037-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184391-
dc.description.abstractObjective: We investigated whether the evaluation of bone mineral density (BMD) provides independent and incremental prognostic value for predicting atherosclerotic cardiovascular disease (ASCVD) in women. Methods: A total of 12 681 women aged 50-80 years (mean, 63.0±7.8 years) who underwent dual-energy X-ray absorptiometry were retrospectively analysed. We assessed the hazard ratio (HR) for ASCVD events (ASCVD death, non-fatal myocardial infarction and ischaemic stroke) according to the BMD or a clinical diagnosis of osteopenia or osteoporosis, with adjustment for clinical risk factors, including age, body mass index, hypertension, type 2 diabetes, hyperlipidaemia, current smoking and previous fracture. We also evaluated whether the addition of BMD or a clinical diagnosis of osteopenia or osteoporosis to clinical risk factors improved the prediction for ASCVD events. Results: In total, 468 women (3.7%) experienced ASCVD events during follow-up (median, 9.2 years). Lower BMD at the lumbar spine, femur neck and total hip was independently associated with higher risk for ASCVD events (adjusted HR per 1-standard deviation decrease in BMD: 1.16, p<0.001; 1.29, p<0.001; 1.38, p<0.001; respectively). A clinical diagnosis of osteoporosis was also independently associated with higher risk for ASCVD events (adjusted HR: 1.79, p<0.001). The addition of BMD or a clinical diagnosis of osteopenia or osteoporosis to clinical risk factors demonstrated significant incremental value in discriminating ASCVD events (addition of total hip BMD, p for difference <0.001). Conclusion: The evaluation of BMD provides independent and incremental prognostic value for ASCVD in women and thus may improve risk stratification in women.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherBMJ Pub. Group.-
dc.relation.isPartOfHEART-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titlePrognostic value of lower bone mineral density in predicting adverse cardiovascular disease in Asian women-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJiesuck Park-
dc.contributor.googleauthorYeonyee Elizabeth Yoon-
dc.contributor.googleauthorKyoung Min Kim-
dc.contributor.googleauthorIn-Chang Hwang-
dc.contributor.googleauthorWonjae Lee-
dc.contributor.googleauthorGoo-Yeong Cho-
dc.identifier.doi10.1136/heartjnl-2020-318764-
dc.contributor.localIdA00295-
dc.relation.journalcodeJ00976-
dc.identifier.eissn1468-201X-
dc.identifier.pmid33963047-
dc.identifier.urlhttps://heart.bmj.com/content/107/13/1040.long-
dc.subject.keywordcoronary artery disease-
dc.contributor.alternativeNameKim, Kyung Min-
dc.contributor.affiliatedAuthor김경민-
dc.citation.volume107-
dc.citation.number13-
dc.citation.startPage1040-
dc.citation.endPage1046-
dc.identifier.bibliographicCitationHEART, Vol.107(13) : 1040-1046, 2021-07-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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