Cited 4 times in
Revisiting the Role of Insulin-like Growth Factor-1 Measurement After Surgical Treatment of Acromegaly
DC Field | Value | Language |
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dc.contributor.author | 구철룡 | - |
dc.contributor.author | 김의현 | - |
dc.contributor.author | 이상국 | - |
dc.contributor.author | 이은직 | - |
dc.contributor.author | 정인호 | - |
dc.contributor.author | 최선아 | - |
dc.contributor.author | 김선호 | - |
dc.date.accessioned | 2021-09-29T01:27:50Z | - |
dc.date.available | 2021-09-29T01:27:50Z | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 0021-972X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184375 | - |
dc.description.abstract | Context: In the management of growth hormone (GH)-secreting pituitary adenomas, the oral glucose tolerance test (OGTT) has been the gold standard not only for diagnoses but also for the determination of biochemical remission. Insulin-like growth factor-1 (IGF-1) is an essential biomarker, although it should be adjusted for both age and sex. Objective: We evaluated whether IGF-1 levels could serve as a reliable alternative to an OGTT for disease monitoring after the surgical treatment of acromegaly. We retrospectively reviewed the medical records of 320 patients who underwent surgical resection of their GH-secreting pituitary tumors at the Severance hospital. Receiver operator characteristic (ROC) analyses were performed to validate the accuracy of IGF-1 levels for the assessment of remission. In addition, regression analyses were performed to identify factors associated with discrepancy between OGTT and IGF-1 levels. Results: Except for 1 week after surgery, ROC analyses showed an area under the curve of greater than 0.8 for IGF-1 at all time points. Of 320 patients, 270 achieved endocrine remission after surgery alone. Among these patients, IGF-1 levels were normalized in 250 patients. The mean duration from surgery to IGF-1 normalization was 4.7 months. Regression analyses demonstrated that risk of failed IGF-1 normalization was increased by 3.1-fold when the tumor invaded the cavernous sinus and increased by 9.0-fold in patients with incomplete tumor removal. Conclusion: IGF-1 level is a reliable alternative to OGTT and plays a valuable role in monitoring acromegaly status. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Endocrine Society | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Revisiting the Role of Insulin-like Growth Factor-1 Measurement After Surgical Treatment of Acromegaly | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | In-Ho Jung | - |
dc.contributor.googleauthor | Seonah Choi | - |
dc.contributor.googleauthor | Cheol Ryong Ku | - |
dc.contributor.googleauthor | Sang-Guk Lee | - |
dc.contributor.googleauthor | Eun Jig Lee | - |
dc.contributor.googleauthor | Sun Ho Kim | - |
dc.contributor.googleauthor | Eui Hyun Kim | - |
dc.identifier.doi | 10.1210/clinem/dgab186 | - |
dc.contributor.localId | A00201 | - |
dc.contributor.localId | A00837 | - |
dc.contributor.localId | A02810 | - |
dc.contributor.localId | A03050 | - |
dc.contributor.localId | A06107 | - |
dc.relation.journalcode | J01318 | - |
dc.identifier.eissn | 1945-7197 | - |
dc.identifier.pmid | 33738470 | - |
dc.identifier.url | https://academic.oup.com/jcem/article/106/7/e2589/6178519 | - |
dc.subject.keyword | Acromegaly | - |
dc.subject.keyword | growth hormone | - |
dc.subject.keyword | insulin-like growth factor-1 | - |
dc.subject.keyword | pituitary adenoma | - |
dc.subject.keyword | remission | - |
dc.subject.keyword | transsphenoidal surgery | - |
dc.contributor.alternativeName | Ku, Cheol Ryong | - |
dc.contributor.affiliatedAuthor | 구철룡 | - |
dc.contributor.affiliatedAuthor | 김의현 | - |
dc.contributor.affiliatedAuthor | 이상국 | - |
dc.contributor.affiliatedAuthor | 이은직 | - |
dc.contributor.affiliatedAuthor | 정인호 | - |
dc.citation.volume | 106 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | e2589 | - |
dc.citation.endPage | e2599 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol.106(7) : e2589-e2599, 2021-06 | - |
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