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Intracranial failure after hippocampal-avoidance prophylactic cranial irradiation in limited-stage small-cell lung cancer patients

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dc.contributor.author김준원-
dc.contributor.author김혜련-
dc.contributor.author윤홍인-
dc.contributor.author이익재-
dc.contributor.author이준교-
dc.contributor.author이창걸-
dc.contributor.author조병철-
dc.contributor.author조연아-
dc.contributor.author홍민희-
dc.contributor.author김혜련-
dc.contributor.author윤홍인-
dc.contributor.author이익재-
dc.contributor.author이준교-
dc.contributor.author이창걸-
dc.contributor.author조병철-
dc.contributor.author조연아-
dc.contributor.author홍민희-
dc.date.accessioned2021-09-29T01:20:14Z-
dc.date.available2021-09-29T01:20:14Z-
dc.date.issued2021-04-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184316-
dc.description.abstractWe evaluated intracranial failure after hippocampus-avoidance-prophylactic cranial irradiation (HA-PCI) for limited-stage small-cell lung cancer (SCLC). Data of 106 patients who received PCI with 25 Gy were retrospectively reviewed. The patients were divided into two groups based on whether they underwent HA-PCI: the HA-PCI group (n = 48) and the conventional PCI (C-PCI) group (n = 58). Twenty-one patients experienced intracranial failure: 11 and 10 patients in the C-PCI and HA-PCI groups, respectively. Using the log-rank test, the intracranial failure rate was not significantly different between the groups (p = 0.215). No clinical factor was significantly associated with intracranial failure in multivariate Cox regression analysis, but HA-PCI tended to be associated with increased incidence of intracranial failure (HR 2.87, 95% CI 0.86-9.58, p = 0.087). Among patients who received HA-PCI, two developed peri-hippocampal recurrence. A higher thoracic radiotherapy dose (≥ 60 Gy) was significantly associated with DFS (HR 0.52, p = 0.048) and OS (HR 0.35, p = 0.003). However, HA-PCI was associated with neither DFS nor OS. Although HA-PCI may be associated with an increased risk of intracranial failure, HA-PCI did not impair disease control or survival. Future prospective randomized trials are needed to reach a definite conclusion.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleIntracranial failure after hippocampal-avoidance prophylactic cranial irradiation in limited-stage small-cell lung cancer patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiation Oncology (방사선종양학교실)-
dc.contributor.googleauthorYeona Cho-
dc.contributor.googleauthorJoongyo Lee-
dc.contributor.googleauthorIk Jae Lee-
dc.contributor.googleauthorJun Won Kim-
dc.contributor.googleauthorJong Geol Baek-
dc.contributor.googleauthorDong Min Jung-
dc.contributor.googleauthorByoung Chul Cho-
dc.contributor.googleauthorMin Hee Hong-
dc.contributor.googleauthorHye Ryun Kim-
dc.contributor.googleauthorChang Geol Lee-
dc.contributor.googleauthorHong In Yoon-
dc.identifier.doi10.1038/s41598-021-86851-6-
dc.contributor.localIdA00958-
dc.contributor.localIdA01166-
dc.contributor.localIdA04777-
dc.contributor.localIdA03055-
dc.contributor.localIdA05800-
dc.contributor.localIdA03240-
dc.contributor.localIdA03822-
dc.contributor.localIdA04680-
dc.contributor.localIdA04393-
dc.contributor.localIdA01166-
dc.contributor.localIdA04777-
dc.contributor.localIdA03055-
dc.contributor.localIdA05800-
dc.contributor.localIdA03240-
dc.contributor.localIdA03822-
dc.contributor.localIdA04680-
dc.contributor.localIdA04393-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid33795826-
dc.contributor.alternativeNameKim, Jun Won-
dc.contributor.affiliatedAuthor김준원-
dc.contributor.affiliatedAuthor김혜련-
dc.contributor.affiliatedAuthor윤홍인-
dc.contributor.affiliatedAuthor이익재-
dc.contributor.affiliatedAuthor이준교-
dc.contributor.affiliatedAuthor이창걸-
dc.contributor.affiliatedAuthor조병철-
dc.contributor.affiliatedAuthor조연아-
dc.contributor.affiliatedAuthor홍민희-
dc.contributor.affiliatedAuthor김혜련-
dc.contributor.affiliatedAuthor윤홍인-
dc.contributor.affiliatedAuthor이익재-
dc.contributor.affiliatedAuthor이준교-
dc.contributor.affiliatedAuthor이창걸-
dc.contributor.affiliatedAuthor조병철-
dc.contributor.affiliatedAuthor조연아-
dc.contributor.affiliatedAuthor홍민희-
dc.citation.volume11-
dc.citation.number1-
dc.citation.startPage7435-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.11(1) : 7435, 2021-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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