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Dysregulation of HOX as a Potential Therapeutic Target in Breast Cancer

Authors
 Ji-Yeon Lee  ;  Myoung Hee Kim 
Citation
 CURRENT MEDICINAL CHEMISTRY, Vol.28 : epub., 2021-06 
Journal Title
CURRENT MEDICINAL CHEMISTRY
ISSN
 0929-8673 
Issue Date
2021-06
Keywords
HOX gene ; HOX cluster ; non-coding RNA ; genomic organization ; 3D structure ; HOX protein ; breast cancer
Abstract
HOX genes belong to the highly conserved homeobox superfamily, responsible for the regulation of various cellular processes that control cell homeostasis, from embryogenesis to carcinogenesis. The abnormal expression of HOX genes is observed in various cancers, including breast cancer; they act as oncogenes or as suppressors of cancer, according to context. In this review, we analyze HOX gene expression patterns in breast cancer and examine their relationship, based on the three-dimensional genome structure of the HOX locus. The presence of non-coding RNAs, embedded within the HOX cluster, and the role of these molecules in breast cancer have been reviewed. We further evaluate the characteristic activity of HOX protein in breast cancer and its therapeutic potential.
Full Text
https://www.eurekaselect.com/187426/article
DOI
10.2174/0929867327666201102115327
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Hee(김명희) ORCID logo https://orcid.org/0000-0001-5652-1452
Lee, Ji Yeon(이지연) ORCID logo https://orcid.org/0000-0002-0670-3095
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184263
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