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Protective effect of controlled blood pressure on risk of dementia in low-risk, grade 1 hypertension
DC Field | Value | Language |
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dc.contributor.author | 김창수 | - |
dc.contributor.author | 김현창 | - |
dc.contributor.author | 박성하 | - |
dc.contributor.author | 이찬주 | - |
dc.date.accessioned | 2021-09-29T01:14:22Z | - |
dc.date.available | 2021-09-29T01:14:22Z | - |
dc.date.issued | 2021-08 | - |
dc.identifier.issn | 0263-6352 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184262 | - |
dc.description.abstract | Objective: High blood pressure (BP) increases the risk of dementia; however, few studies have reported on the risk of dementia in patients with low-risk, early-grade hypertension. We investigated the protective effect of controlled BP on risk of dementia in treated, low-risk, grade 1 hypertensive patients from the entire National Health Insurance Service National Health Examinee cohort. Methods: We selected grade 1 hypertension (140-159/90-99 mmHg) patients with low risk, diagnosed in 2005-2006. All patients (N = 128 665) were classified into controlled (average BP < 140/90 mmHg during the follow-up) and uncontrolled (average BP ≥ 140/90 mmHg) BP groups and followed up until 2015. The risk of dementia was estimated using Cox proportional hazard model after adjustments for propensity score. Results: Average BP was 131/81 mmHg in the controlled group (N = 49 408) and 144/87 mmHg in the uncontrolled group (N = 99 257). Overall dementia incidence rates in controlled and uncontrolled groups were 4.9 and 8.1 per 1000 person-year, respectively. The controlled group showed lower risk of overall dementia, Alzheimer's disease, and vascular dementia than the uncontrolled group. The controlled group had a low risk of vascular dementia at all ages, especially in the younger group (age <60). The optimal BP level associated with the lowest risk of dementia was 130 to less than 140 mmHg for SBP and 70 to less than 80 mmHg for DBP. Conclusion: We concluded that among even low-risk and grade 1 hypertension patients, controlled BP significantly reduced the risk of dementia, including Alzheimer's disease and vascular dementia. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | JOURNAL OF HYPERTENSION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Protective effect of controlled blood pressure on risk of dementia in low-risk, grade 1 hypertension | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Preventive Medicine (예방의학교실) | - |
dc.contributor.googleauthor | Chan Joo Lee | - |
dc.contributor.googleauthor | Jinseub Hwang | - |
dc.contributor.googleauthor | Chae Young Kang | - |
dc.contributor.googleauthor | Hyeon-Chang Kim | - |
dc.contributor.googleauthor | Dong-Ryeol Ryu | - |
dc.contributor.googleauthor | Sang-Hyun Ihm | - |
dc.contributor.googleauthor | Yong-Jin Kim | - |
dc.contributor.googleauthor | Jin-Ho Shin | - |
dc.contributor.googleauthor | Wook Bum Pyun | - |
dc.contributor.googleauthor | Changsoo Kim | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.identifier.doi | 10.1097/HJH.0000000000002820 | - |
dc.contributor.localId | A01042 | - |
dc.contributor.localId | A01142 | - |
dc.contributor.localId | A01512 | - |
dc.contributor.localId | A03238 | - |
dc.relation.journalcode | J01448 | - |
dc.identifier.eissn | 1473-5598 | - |
dc.identifier.pmid | 33710170 | - |
dc.identifier.url | https://journals.lww.com/jhypertension/Fulltext/2021/08000/Protective_effect_of_controlled_blood_pressure_on.22.aspx | - |
dc.contributor.alternativeName | Kim, Chang Soo | - |
dc.contributor.affiliatedAuthor | 김창수 | - |
dc.contributor.affiliatedAuthor | 김현창 | - |
dc.contributor.affiliatedAuthor | 박성하 | - |
dc.contributor.affiliatedAuthor | 이찬주 | - |
dc.citation.volume | 39 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 1662 | - |
dc.citation.endPage | 1669 | - |
dc.identifier.bibliographicCitation | JOURNAL OF HYPERTENSION, Vol.39(8) : 1662-1669, 2021-08 | - |
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