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Protective effect of controlled blood pressure on risk of dementia in low-risk, grade 1 hypertension

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dc.contributor.author김창수-
dc.contributor.author김현창-
dc.contributor.author박성하-
dc.contributor.author이찬주-
dc.contributor.author김현창-
dc.contributor.author박성하-
dc.contributor.author이찬주-
dc.date.accessioned2021-09-29T01:14:22Z-
dc.date.available2021-09-29T01:14:22Z-
dc.date.issued2021-08-
dc.identifier.issn0263-6352-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184262-
dc.description.abstractObjective: High blood pressure (BP) increases the risk of dementia; however, few studies have reported on the risk of dementia in patients with low-risk, early-grade hypertension. We investigated the protective effect of controlled BP on risk of dementia in treated, low-risk, grade 1 hypertensive patients from the entire National Health Insurance Service National Health Examinee cohort. Methods: We selected grade 1 hypertension (140-159/90-99 mmHg) patients with low risk, diagnosed in 2005-2006. All patients (N = 128 665) were classified into controlled (average BP < 140/90 mmHg during the follow-up) and uncontrolled (average BP ≥ 140/90 mmHg) BP groups and followed up until 2015. The risk of dementia was estimated using Cox proportional hazard model after adjustments for propensity score. Results: Average BP was 131/81 mmHg in the controlled group (N = 49 408) and 144/87 mmHg in the uncontrolled group (N = 99 257). Overall dementia incidence rates in controlled and uncontrolled groups were 4.9 and 8.1 per 1000 person-year, respectively. The controlled group showed lower risk of overall dementia, Alzheimer's disease, and vascular dementia than the uncontrolled group. The controlled group had a low risk of vascular dementia at all ages, especially in the younger group (age <60). The optimal BP level associated with the lowest risk of dementia was 130 to less than 140 mmHg for SBP and 70 to less than 80 mmHg for DBP. Conclusion: We concluded that among even low-risk and grade 1 hypertension patients, controlled BP significantly reduced the risk of dementia, including Alzheimer's disease and vascular dementia.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfJOURNAL OF HYPERTENSION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleProtective effect of controlled blood pressure on risk of dementia in low-risk, grade 1 hypertension-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Preventive Medicine (예방의학교실)-
dc.contributor.googleauthorChan Joo Lee-
dc.contributor.googleauthorJinseub Hwang-
dc.contributor.googleauthorChae Young Kang-
dc.contributor.googleauthorHyeon-Chang Kim-
dc.contributor.googleauthorDong-Ryeol Ryu-
dc.contributor.googleauthorSang-Hyun Ihm-
dc.contributor.googleauthorYong-Jin Kim-
dc.contributor.googleauthorJin-Ho Shin-
dc.contributor.googleauthorWook Bum Pyun-
dc.contributor.googleauthorChangsoo Kim-
dc.contributor.googleauthorSungha Park-
dc.identifier.doi10.1097/HJH.0000000000002820-
dc.contributor.localIdA01042-
dc.contributor.localIdA01142-
dc.contributor.localIdA01512-
dc.contributor.localIdA03238-
dc.contributor.localIdA01142-
dc.contributor.localIdA01512-
dc.contributor.localIdA03238-
dc.relation.journalcodeJ01448-
dc.identifier.eissn1473-5598-
dc.identifier.pmid33710170-
dc.identifier.urlhttps://journals.lww.com/jhypertension/Fulltext/2021/08000/Protective_effect_of_controlled_blood_pressure_on.22.aspx-
dc.contributor.alternativeNameKim, Chang Soo-
dc.contributor.affiliatedAuthor김창수-
dc.contributor.affiliatedAuthor김현창-
dc.contributor.affiliatedAuthor박성하-
dc.contributor.affiliatedAuthor이찬주-
dc.contributor.affiliatedAuthor김현창-
dc.contributor.affiliatedAuthor박성하-
dc.contributor.affiliatedAuthor이찬주-
dc.citation.volume39-
dc.citation.number8-
dc.citation.startPage1662-
dc.citation.endPage1669-
dc.identifier.bibliographicCitationJOURNAL OF HYPERTENSION, Vol.39(8) : 1662-1669, 2021-08-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers

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