Cited 1 times in
Direct-Acting Antivirals Improve Treatment Outcomes in Patients with Hepatitis C Virus-Related Hepatocellular Carcinoma Treated with Transarterial Chemoembolization: A Nationwide, Multi-center, Retrospective Cohort Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김도영 | - |
dc.contributor.author | 김범경 | - |
dc.contributor.author | 김승업 | - |
dc.contributor.author | 박준용 | - |
dc.contributor.author | 안상훈 | - |
dc.contributor.author | 이현웅 | - |
dc.contributor.author | 한광협 | - |
dc.contributor.author | 현혜경 | - |
dc.date.accessioned | 2021-09-29T01:13:15Z | - |
dc.date.available | 2021-09-29T01:13:15Z | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 0163-2116 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184253 | - |
dc.description.abstract | Background and aims: The influence of direct-acting antivirals (DAAs) on chronic hepatitis C (CHC)-related hepatocellular carcinoma (HCC) remains controversial. We investigated the effect of eradicating CHC using DAAs on treatment outcomes in patients with CHC-related HCC treated with transarterial chemoembolization (TACE). Methods: This nationwide, multi-center, retrospective study recruited patients with CHC-related HCC treated with TACE as the first-line anti-cancer treatment, and who achieved a sustained virological response (SVR) using DAAs (DAA group) between 2006 and 2017. Patients achieving an SVR following interferon-based treatment (IFN group) and those without treatment (control group) were also recruited for comparison. Results: A total of 425 patients were eligible for the study. Of these, 356 (83.8%), 26 (6.1%), and 43 (10.1%) were allocated to the control, IFN, and DAA groups, respectively. A multivariate analysis showed that liver cirrhosis, segmental portal vein thrombosis, and larger maximal tumor size independently predicted an increased risk of progression (all p < 0.05), whereas, the DAA group (vs. IFN and control groups) independently predicted a reduced risk of progression (hazard ratio (HR) = 0.630, 95% confidence interval 0.411-0.966, p = 0.034). The cumulative incidence rate of HCC progression in the DAA group was significantly lower than that in the IFN and control groups (p = 0.033, log-rank test). In addition, the DAA group (vs. IFN and control groups) was independently associated with a reduced risk of mortality (p = 0.042). Conclusions: DAA treatment provided significantly prolonged progression-free survival in patients with CHC-related HCC treated with TACE compared to that in patients administered IFN or no treatment. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer Science + Business Media | - |
dc.relation.isPartOf | DIGESTIVE DISEASES AND SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Direct-Acting Antivirals Improve Treatment Outcomes in Patients with Hepatitis C Virus-Related Hepatocellular Carcinoma Treated with Transarterial Chemoembolization: A Nationwide, Multi-center, Retrospective Cohort Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Hye Kyung Hyun | - |
dc.contributor.googleauthor | Eun Ju Cho | - |
dc.contributor.googleauthor | Soo Young Park | - |
dc.contributor.googleauthor | Young Mi Hong | - |
dc.contributor.googleauthor | Soon Sun Kim | - |
dc.contributor.googleauthor | Hwi Young Kim | - |
dc.contributor.googleauthor | Nae-Yun Heo | - |
dc.contributor.googleauthor | Jung Gil Park | - |
dc.contributor.googleauthor | Dong Hyun Sinn | - |
dc.contributor.googleauthor | Wonseok Kang | - |
dc.contributor.googleauthor | Song Won Jeong | - |
dc.contributor.googleauthor | Myeong Jun Song | - |
dc.contributor.googleauthor | Hana Park | - |
dc.contributor.googleauthor | Danbi Lee | - |
dc.contributor.googleauthor | Yong Sun Lee | - |
dc.contributor.googleauthor | Sung Bum Cho | - |
dc.contributor.googleauthor | Chan Sik An | - |
dc.contributor.googleauthor | Hyung Jin Rhee | - |
dc.contributor.googleauthor | Hyun Woong Lee | - |
dc.contributor.googleauthor | Beom Kyung Kim | - |
dc.contributor.googleauthor | Jun Yong Park | - |
dc.contributor.googleauthor | Do Young Kim | - |
dc.contributor.googleauthor | Sang Hoon Ahn | - |
dc.contributor.googleauthor | Kwang-Hyub Han | - |
dc.contributor.googleauthor | Jeong-Hoon Lee | - |
dc.contributor.googleauthor | Su Jong Yu | - |
dc.contributor.googleauthor | Yoon Jun Kim | - |
dc.contributor.googleauthor | Jung-Hwan Yoon | - |
dc.contributor.googleauthor | Won Young Tak | - |
dc.contributor.googleauthor | Young Oh Kweon | - |
dc.contributor.googleauthor | Ki Tae Yoon | - |
dc.contributor.googleauthor | Mong Cho | - |
dc.contributor.googleauthor | Jae Youn Cheong | - |
dc.contributor.googleauthor | Seung Ha Park | - |
dc.contributor.googleauthor | Seung Up Kim | - |
dc.identifier.doi | 10.1007/s10620-020-06533-7 | - |
dc.contributor.localId | A00385 | - |
dc.contributor.localId | A00487 | - |
dc.contributor.localId | A00654 | - |
dc.contributor.localId | A01675 | - |
dc.contributor.localId | A02226 | - |
dc.contributor.localId | A03292 | - |
dc.contributor.localId | A04268 | - |
dc.relation.journalcode | J00737 | - |
dc.identifier.eissn | 1573-2568 | - |
dc.identifier.pmid | 32856240 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs10620-020-06533-7 | - |
dc.subject.keyword | Direct-acting antiviral | - |
dc.subject.keyword | Hepatitis C virus | - |
dc.subject.keyword | Hepatocellular carcinoma | - |
dc.subject.keyword | Progression | - |
dc.subject.keyword | Transarterial chemoembolization | - |
dc.contributor.alternativeName | Kim, Do Young | - |
dc.contributor.affiliatedAuthor | 김도영 | - |
dc.contributor.affiliatedAuthor | 김범경 | - |
dc.contributor.affiliatedAuthor | 김승업 | - |
dc.contributor.affiliatedAuthor | 박준용 | - |
dc.contributor.affiliatedAuthor | 안상훈 | - |
dc.contributor.affiliatedAuthor | 이현웅 | - |
dc.contributor.affiliatedAuthor | 한광협 | - |
dc.citation.volume | 66 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 2427 | - |
dc.citation.endPage | 2438 | - |
dc.identifier.bibliographicCitation | DIGESTIVE DISEASES AND SCIENCES, Vol.66(7) : 2427-2438, 2021-07 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.