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Increased resting-state cerebellar-cortical connectivity in breast cancer survivors with cognitive complaints after chemotherapy

DC Field Value Language
dc.contributor.author남궁기-
dc.contributor.author박혜윤-
dc.contributor.author손주혁-
dc.contributor.author안석균-
dc.contributor.author이은-
dc.contributor.author박혜윤-
dc.contributor.author손주혁-
dc.contributor.author안석균-
dc.contributor.author이은-
dc.date.accessioned2021-09-29T01:10:24Z-
dc.date.available2021-09-29T01:10:24Z-
dc.date.issued2021-06-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184233-
dc.description.abstractCognitive complaints after chemotherapy are common in breast cancer patients, but the neural bases for these complaints remain unclear. This pilot study explored resting-state functional connectivity (FC) as a marker of subtle cognitive changes in breast cancer patients who experience cognitive complaints. Chemotherapy-treated (n = 20, at least 6 months off therapy) and untreated (n = 17, disease-control) female breast cancer patients with cognitive complaints and healthy controls (n = 20) were recruited. The FC of the right dorsolateral prefrontal cortex was calculated, and any correlations between this FC and neuropsychological assessments were determined. Chemotherapy-treated patients with cognitive complaints displayed increased FC between the right dorsolateral prefrontal cortex and both the contralateral cerebellar lobule VII and the cerebellar vermis XI, compared to the disease-control and healthy-control groups, despite unimpaired neuropsychological performance. The increased FC was negatively correlated with executive function and attention in breast cancer survivors with cognitive complaints. Our pilot study findings provide evidence that cerebellar-cortical FC changes may be a pathophysiological basis for chemotherapy-related cognitive complaints. In addition, the FC changes have the potential to reflect minor or compensated cognitive function impairment in breast cancer patients.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleIncreased resting-state cerebellar-cortical connectivity in breast cancer survivors with cognitive complaints after chemotherapy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Psychiatry (정신과학교실)-
dc.contributor.googleauthorHye Yoon Park-
dc.contributor.googleauthorHyeongrae Lee-
dc.contributor.googleauthorJoohyuk Sohn-
dc.contributor.googleauthorSuk Kyoon An-
dc.contributor.googleauthorKee Namkoong-
dc.contributor.googleauthorEun Lee-
dc.identifier.doi10.1038/s41598-021-91447-1-
dc.contributor.localIdA01240-
dc.contributor.localIdA05542-
dc.contributor.localIdA01995-
dc.contributor.localIdA02227-
dc.contributor.localIdA03032-
dc.contributor.localIdA05542-
dc.contributor.localIdA01995-
dc.contributor.localIdA02227-
dc.contributor.localIdA03032-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid34103606-
dc.contributor.alternativeNameNamkoong, Kee-
dc.contributor.affiliatedAuthor남궁기-
dc.contributor.affiliatedAuthor박혜윤-
dc.contributor.affiliatedAuthor손주혁-
dc.contributor.affiliatedAuthor안석균-
dc.contributor.affiliatedAuthor이은-
dc.contributor.affiliatedAuthor박혜윤-
dc.contributor.affiliatedAuthor손주혁-
dc.contributor.affiliatedAuthor안석균-
dc.contributor.affiliatedAuthor이은-
dc.citation.volume11-
dc.citation.number1-
dc.citation.startPage12105-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.11(1) : 12105, 2021-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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