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Fibrosis-5 predicts end-stage renal disease in patients with microscopic polyangiitis and granulomatosis with polyangiitis without substantial liver diseases

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dc.contributor.author박용범-
dc.contributor.author송정식-
dc.contributor.author이상원-
dc.date.accessioned2021-09-29T01:10:02Z-
dc.date.available2021-09-29T01:10:02Z-
dc.date.issued2021-07-
dc.identifier.issn1591-8890-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184230-
dc.description.abstractWe previously reported that fibrosis-4 (FIB-4) was associated with poor outcomes of microscopic polyangiitis (MPA) and granuloma with polyangiitis (GPA). We also investigated the potential of FIB-5, a novel index, in predicting all-cause mortality and end-stage renal disease (ESRD) during follow-up in patients with MPA and GPA without substantial liver diseases. Clinical and laboratory data at diagnosis were collected by reviewing the medical records of 180 patients with MPA and GPA. FIB-5 was obtained by a following equation: FIB-5 = (serum albumin (g/L) × 0.3 + platelet count (109/L) × 0.05) - (alkaline phosphatase (IU/L) × 0.014 + aspartate aminotransferase/alanine aminotransferase ratio × 6 + 14). The median age of the patients at diagnosis was 61.0 years. FIB-5 at diagnosis could not reflect the cross-sectional vasculitis activity. The cutoffs of FIB-5 for poor outcomes was set as 0.82 (the lowest tertile) and -0.42 (the lowest quartile) at diagnosis. In Kaplan-Meier survival analysis, patients with FIB-5 < 0.82 and those with FIB-5 < -0.42 exhibited lower ESRD-free survival rates than those without. However, it could not predict all-cause mortality. In multivariable Cox hazards analysis, both FFS (Hazard ratio (HR) 1.554) and FIB-5 < 0.82 (HR 2.096) as well as both FFS (HR 1.534) and FIB-5 < -0.42 (HR 2.073) at diagnosis independently predicted ESRD during follow-up. In conclusion, FIB-5 < 0.82 and FIB-5 < -0.42 at diagnosis could predict the occurrence of ESRD, but not all-cause mortality, during follow-up in patients with MPA and GPA without substantial liver diseases.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer-Verlag Italia-
dc.relation.isPartOfCLINICAL AND EXPERIMENTAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleFibrosis-5 predicts end-stage renal disease in patients with microscopic polyangiitis and granulomatosis with polyangiitis without substantial liver diseases-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorHyeok Chan Kwon-
dc.contributor.googleauthorJason Jungsik Song-
dc.contributor.googleauthorYong-Beom Park-
dc.contributor.googleauthorSang-Won Lee-
dc.identifier.doi10.1007/s10238-021-00691-2-
dc.contributor.localIdA01579-
dc.contributor.localIdA02057-
dc.contributor.localIdA02824-
dc.relation.journalcodeJ03545-
dc.identifier.eissn1591-9528-
dc.identifier.pmid33611672-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs10238-021-00691-2-
dc.subject.keywordEnd-stage renal disease-
dc.subject.keywordFIB-5-
dc.subject.keywordGranulomatosis with polyangiitis-
dc.subject.keywordMicroscopic polyangiitis-
dc.subject.keywordPrediction-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.affiliatedAuthor박용범-
dc.contributor.affiliatedAuthor송정식-
dc.contributor.affiliatedAuthor이상원-
dc.citation.volume21-
dc.citation.number3-
dc.citation.startPage399-
dc.citation.endPage406-
dc.identifier.bibliographicCitationCLINICAL AND EXPERIMENTAL MEDICINE, Vol.21(3) : 399-406, 2021-07-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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