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Expression of Organic Anion Transporting Polypeptides in an H-Ras 12V Transgenic Mouse Model of Spontaneous Hepatocellular Carcinoma
DC Field | Value | Language |
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dc.contributor.author | 최혜진 | - |
dc.date.accessioned | 2021-09-29T01:04:34Z | - |
dc.date.available | 2021-09-29T01:04:34Z | - |
dc.date.issued | 2021-07 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184179 | - |
dc.description.abstract | Purpose: Expression of organic anion transporting polypeptides (OATPs) 1B1/1B3 in hepatocellular carcinoma (HCC) induces a paradoxical enhancement of gadoxetic acid on liver magnetic resonance imaging (MRI). We examined the expression profile of OATPs with regard to tumor differentiation in a genetically modified H-Ras 12V mouse model of spontaneous HCC that undergoes multistep hepatocarcinogenesis with minimal inter-individual variation. Materials and methods: Tumor nodules were harvested from transgenic H-Ras 12V mice. Hematoxylin and eosin-stained slides were examined for tumor differentiation and high-grade pathological components (tumor necrosis, thickened trabeculae, or vascular invasion). Immunohistochemistry of OATP 1B1/1B3 was performed, and OATP expression was assessed. Results: We examined well-differentiated HCCs (n=59) in which high-grade pathological components were absent (n=49) or present (n=10). Among the well-differentiated HCCs without high-grade pathological components (n=49), OATP expression was negative, weak positive, and moderate positive in 23, 17, and nine cases, respectively. Among the well-differentiated HCCs with high-grade pathological components (n=10), OATP expression was negative, weak positive, and moderate positive in one, two, and seven cases, respectively. The ratio of positive OATP 1B1/1B3 expressing tumors was higher in HCCs with high-grade pathological components than in those without high-grade pathological components (p=0.004). Conclusion: Our findings support those of previous clinical studies that have reported the frequent appearance of gadoxetic acid-enhanced MRI in moderately differentiated HCC. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Carcinoma, Hepatocellular* / diagnostic imaging | - |
dc.subject.MESH | Carcinoma, Hepatocellular* / genetics | - |
dc.subject.MESH | Contrast Media | - |
dc.subject.MESH | Gadolinium DTPA | - |
dc.subject.MESH | Liver Neoplasms* / diagnostic imaging | - |
dc.subject.MESH | Liver Neoplasms* / genetics | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Transgenic | - |
dc.subject.MESH | Organic Anion Transporters* | - |
dc.subject.MESH | Peptides | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Expression of Organic Anion Transporting Polypeptides in an H-Ras 12V Transgenic Mouse Model of Spontaneous Hepatocellular Carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Honsou Kim | - |
dc.contributor.googleauthor | Junjeong Choi | - |
dc.contributor.googleauthor | Dae Yeul Yu | - |
dc.contributor.googleauthor | Hye Jin Choi | - |
dc.identifier.doi | 10.3349/ymj.2021.62.7.622 | - |
dc.contributor.localId | A04219 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 34164960 | - |
dc.subject.keyword | Carcinoma, hepatocellular | - |
dc.subject.keyword | gadolinium ethoxybenzyl DTPA | - |
dc.subject.keyword | magnetic resonance imaging | - |
dc.contributor.alternativeName | Choi, Hye Jin | - |
dc.contributor.affiliatedAuthor | 최혜진 | - |
dc.citation.volume | 62 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 622 | - |
dc.citation.endPage | 630 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.62(7) : 622-630, 2021-07 | - |
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