Cited 4 times in
Effect of Cochlear Implantation on Hearing Fluctuation in Patients with Biallelic SLC26A4 Variants
DC Field | Value | Language |
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dc.contributor.author | 나지나 | - |
dc.contributor.author | 정진세 | - |
dc.contributor.author | 최재영 | - |
dc.contributor.author | 이현진 | - |
dc.date.accessioned | 2021-09-29T01:02:15Z | - |
dc.date.available | 2021-09-29T01:02:15Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.issn | 1420-3030 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184156 | - |
dc.description.abstract | Introduction: Fluctuating hearing loss is a distinctive feature caused by SLC26A4 variants. We investigated whether cochlear implantation had protective or deleterious effect on hearing fluctuation in patients with biallelic SLC26A4 variants. Methods: Patients with biallelic SLC26A4 variants (N = 16; age = 10.24 ± 9.20 years) who had unilateral cochlear implantation and consecutive postsurgical, bilateral pure-tone audiograms more than 3 times were selected. We retrospectively reviewed the patients' medical records from 2008 to 2019 obtained from a tertiary medical center and used the auditory threshold change (Shift) over time as a marker of hearing fluctuation. Fluctuation events were counted, and the Shift of the implanted and contralateral ears was compared using logistic regression with a generalized estimating equation and linear mixed model. A total of 178 values were included. Results: The odds of fluctuating hearing frequency were 11.185-fold higher in the unimplanted ears than in the implanted ears postoperatively (p = 0.001). The extent of fluctuation at 250 and 500 Hz was also significantly lower in the implanted ears than in the unimplanted ears after adjusting for every other effect (p = 0.003 and p < 0.001, respectively). Notably, higher residual hearing was rather associated with lesser fluctuation in frequency and the extent of fluctuation at 500 Hz, indicating residual hearing function is not the positive predictor for hearing fluctuation. Conclusion: In patients with biallelic SLC26A4 variants, cochlear implantation may reduce the frequency and extent of hearing fluctuations. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Karger | - |
dc.relation.isPartOf | AUDIOLOGY AND NEURO-OTOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Audiometry, Pure-Tone | - |
dc.subject.MESH | Auditory Threshold / physiology* | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Cochlear Implantation* | - |
dc.subject.MESH | Cochlear Implants* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hearing / genetics | - |
dc.subject.MESH | Hearing / physiology* | - |
dc.subject.MESH | Hearing Loss / genetics | - |
dc.subject.MESH | Hearing Loss / surgery* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Sulfate Transporters / genetics* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Young Adult | - |
dc.title | Effect of Cochlear Implantation on Hearing Fluctuation in Patients with Biallelic SLC26A4 Variants | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Otorhinolaryngology (이비인후과학교실) | - |
dc.contributor.googleauthor | Gina Na | - |
dc.contributor.googleauthor | Jeon Mi Lee | - |
dc.contributor.googleauthor | Hyun Jin Lee | - |
dc.contributor.googleauthor | Yeonsu Jeong | - |
dc.contributor.googleauthor | Jinsei Jung | - |
dc.contributor.googleauthor | Jae Young Choi | - |
dc.identifier.doi | 10.1159/000508858 | - |
dc.contributor.localId | A04923 | - |
dc.contributor.localId | A03742 | - |
dc.contributor.localId | A04173 | - |
dc.relation.journalcode | J02972 | - |
dc.identifier.eissn | 1421-9700 | - |
dc.identifier.pmid | 32877901 | - |
dc.identifier.url | https://www.karger.com/Article/Abstract/508858 | - |
dc.subject.keyword | Cochlear implantation | - |
dc.subject.keyword | DFNB4 | - |
dc.subject.keyword | Hearing fluctuation | - |
dc.subject.keyword | Pendrin | - |
dc.subject.keyword | SLC26A4 | - |
dc.contributor.alternativeName | Na, Gina | - |
dc.contributor.affiliatedAuthor | 나지나 | - |
dc.contributor.affiliatedAuthor | 정진세 | - |
dc.contributor.affiliatedAuthor | 최재영 | - |
dc.citation.volume | 26 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 111 | - |
dc.citation.endPage | 120 | - |
dc.identifier.bibliographicCitation | AUDIOLOGY AND NEURO-OTOLOGY, Vol.26(2) : 111-120, 2021-02 | - |
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