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Splenic uptake on FDG PET/CT correlates with Kikuchi-Fujimoto disease severity

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dc.contributor.author구남수-
dc.contributor.author김정호-
dc.contributor.author박윤수-
dc.contributor.author성혜-
dc.contributor.author송영구-
dc.contributor.author안진영-
dc.contributor.author염준섭-
dc.contributor.author정수진-
dc.contributor.author정용휴-
dc.contributor.author조응혁-
dc.contributor.author최준용-
dc.contributor.author김준형-
dc.date.accessioned2021-09-29T01:01:18Z-
dc.date.available2021-09-29T01:01:18Z-
dc.date.issued2021-05-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184149-
dc.description.abstractKikuchi-Fujimoto disease (KFD) is usually self-limiting, but prolonged systemic symptoms often result in frequent hospital visits, long admission durations, or missed workdays. We investigated the role of fluorine-18 fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in assessing KFD severity. We reviewed the records of 31 adult patients with pathologically confirmed KFD who underwent 18F-FDG PET/CT between November 2007 and April 2018 at a tertiary-care referral hospital. Disease severity was assessed using criteria based on clinical manifestations of advanced KFD. Systemic activated lymph nodes and severity of splenic activation were determined using semi-quantitative and volumetric PET/CT parameters. The median of the mean splenic standardized uptake value (SUVmean) was higher in patients with severe KFD than those with mild KFD (2.38 ± 1.18 vs. 1.79 ± 0.99, p = 0.058). Patients with severe KFD had more systemically activated volume and glycolytic activity than those with mild KFD (total lesion glycolysis: 473.5 ± 504.4 vs. 201.6 ± 363.5, p = 0.024). Multivariate logistic regression showed that myalgia (odds ratio [OR] 0.035; 95% confidence interval [CI] 0.001-0.792; p = 0.035), total lymph node SUVmax (cutoff 9.27; OR 24.734; 95% CI 1.323-462.407; p = 0.032), and spleen SUVmean (cutoff 1.79; OR 37.770; 95% CI 1.769-806.583; p = 0.020) were significantly associated with severe KFD. 18F-FDG PET/CT could be useful in assessing KFD severity.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleSplenic uptake on FDG PET/CT correlates with Kikuchi-Fujimoto disease severity-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorHye Seong-
dc.contributor.googleauthorYong Hyu Jeong-
dc.contributor.googleauthorWoon Ji Lee-
dc.contributor.googleauthorJun Hyoung Kim-
dc.contributor.googleauthorJung Ho Kim-
dc.contributor.googleauthorJin Young Ahn-
dc.contributor.googleauthorSu Jin Jeong-
dc.contributor.googleauthorJun Yong Choi-
dc.contributor.googleauthorYoon Soo Park-
dc.contributor.googleauthorJoon Sup Yeom-
dc.contributor.googleauthorYoung Goo Song-
dc.contributor.googleauthorArthur Cho-
dc.contributor.googleauthorNam Su Ku-
dc.identifier.doi10.1038/s41598-021-90350-z-
dc.contributor.localIdA00189-
dc.contributor.localIdA00902-
dc.contributor.localIdA01598-
dc.contributor.localIdA05140-
dc.contributor.localIdA02037-
dc.contributor.localIdA02267-
dc.contributor.localIdA02353-
dc.contributor.localIdA03638-
dc.contributor.localIdA05554-
dc.contributor.localIdA03887-
dc.contributor.localIdA04191-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid34035381-
dc.contributor.alternativeNameKu, Nam Su-
dc.contributor.affiliatedAuthor구남수-
dc.contributor.affiliatedAuthor김정호-
dc.contributor.affiliatedAuthor박윤수-
dc.contributor.affiliatedAuthor성혜-
dc.contributor.affiliatedAuthor송영구-
dc.contributor.affiliatedAuthor안진영-
dc.contributor.affiliatedAuthor염준섭-
dc.contributor.affiliatedAuthor정수진-
dc.contributor.affiliatedAuthor정용휴-
dc.contributor.affiliatedAuthor조응혁-
dc.contributor.affiliatedAuthor최준용-
dc.citation.volume11-
dc.citation.number1-
dc.citation.startPage10836-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.11(1) : 10836, 2021-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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