Cited 9 times in
TERT promoter mutations in penile squamous cell carcinoma: high frequency in non-HPV-related type and association with favorable clinicopathologic features
DC Field | Value | Language |
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dc.contributor.author | 김상겸 | - |
dc.contributor.author | 조남훈 | - |
dc.date.accessioned | 2021-09-29T00:56:24Z | - |
dc.date.available | 2021-09-29T00:56:24Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.issn | 0171-5216 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184114 | - |
dc.description.abstract | Purpose: Penile carcinoma is a rare malignant neoplasm with a largely unknown molecular pathogenesis. Telomerase reverse transcriptase promoter (TERT-p) mutations have been detected in several types of human malignancies. The aim of this study was to investigate the presence of TERT-p mutations in penile squamous cell carcinomas (SCCs) and their associations with clinicopathologic features. Methods: In this retrospective study, Sanger sequencing was performed to detect TERT-p mutations in formalin-fixed paraffin-embedded tissue samples from 37 patients with penile SCC, 16 patients with cutaneous SCC, and 4 patients with non-neoplastic penile/skin tissue. The expression of p16INK4a and Ki-67 was investigated via immunohistochemistry. Associations of TERT-p mutation with clinicopathological factors, immunohistochemical results, and clinical outcome were statistically analyzed. Results: Recurrent TERT-p mutations were identified in 18 out of 37 (48.6%) penile SCCs, including all 3 carcinoma in situ cases. TERT-p mutations were significantly more frequent in non-human papilloma virus (HPV)-related penile SCC types than in non-HPV-related penile SCC based on both histologic classification and p16INK4a immunoreactivity. Furthermore, TERT-p mutation was associated with a low histologic grade, low mitotic count, absence of necrosis, low Ki-67/MIB-1 labeling index, and absence of lymph node or distant metastasis. Conclusion: Our study shows TERT-p mutations are the most frequent somatic mutations in penile SCC. In addition, TERT-p mutations are far more frequent in non-HPV-related penile SCC than in HPV-related penile SCC, indicating TERT-p mutations may have a role in tumorigenesis distinct from HPV-related penile SCC. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English, German | - |
dc.publisher | Springer-Verlag | - |
dc.relation.isPartOf | JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Biomarkers, Tumor / genetics* | - |
dc.subject.MESH | Biomarkers, Tumor / metabolism | - |
dc.subject.MESH | Carcinoma, Squamous Cell / genetics | - |
dc.subject.MESH | Carcinoma, Squamous Cell / pathology* | - |
dc.subject.MESH | Carcinoma, Squamous Cell / virology | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Cyclin-Dependent Kinase Inhibitor p16 / genetics | - |
dc.subject.MESH | Cyclin-Dependent Kinase Inhibitor p16 / metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Ki-67 Antigen / genetics | - |
dc.subject.MESH | Ki-67 Antigen / metabolism | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mutation* | - |
dc.subject.MESH | Papillomaviridae / isolation & purification | - |
dc.subject.MESH | Papillomavirus Infections / complications* | - |
dc.subject.MESH | Papillomavirus Infections / virology | - |
dc.subject.MESH | Penile Neoplasms / genetics | - |
dc.subject.MESH | Penile Neoplasms / pathology* | - |
dc.subject.MESH | Penile Neoplasms / virology | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Promoter Regions, Genetic* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Survival Rate | - |
dc.subject.MESH | Telomerase / genetics* | - |
dc.title | TERT promoter mutations in penile squamous cell carcinoma: high frequency in non-HPV-related type and association with favorable clinicopathologic features | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학교실) | - |
dc.contributor.googleauthor | Sang Kyum Kim | - |
dc.contributor.googleauthor | Jang-Hee Kim | - |
dc.contributor.googleauthor | Jae Ho Han | - |
dc.contributor.googleauthor | Nam Hoon Cho | - |
dc.contributor.googleauthor | Se Joong Kim | - |
dc.contributor.googleauthor | Sun Il Kim | - |
dc.contributor.googleauthor | Seol Ho Choo | - |
dc.contributor.googleauthor | Ji Su Kim | - |
dc.contributor.googleauthor | Bumhee Park | - |
dc.contributor.googleauthor | Ji Eun Kwon | - |
dc.identifier.doi | 10.1007/s00432-021-03514-9 | - |
dc.contributor.localId | A00520 | - |
dc.contributor.localId | A03812 | - |
dc.relation.journalcode | J01283 | - |
dc.identifier.eissn | 1432-1335 | - |
dc.identifier.pmid | 33635430 | - |
dc.subject.keyword | Human papillomavirus | - |
dc.subject.keyword | Penile cancer | - |
dc.subject.keyword | TERT promoter | - |
dc.subject.keyword | Telomerase | - |
dc.contributor.alternativeName | Kim, Sang Kyum | - |
dc.contributor.affiliatedAuthor | 김상겸 | - |
dc.contributor.affiliatedAuthor | 조남훈 | - |
dc.citation.volume | 147 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1125 | - |
dc.citation.endPage | 1135 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, Vol.147(4) : 1125-1135, 2021-04 | - |
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