Cited 29 times in
Current status of the diagnosis and treatment of hemophagocytic lymphohistiocytosis in adults
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김유리 | - |
dc.date.accessioned | 2021-09-29T00:51:07Z | - |
dc.date.available | 2021-09-29T00:51:07Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.issn | 2287-979X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184068 | - |
dc.description.abstract | Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of defective apoptosis, a disruption of the regulatory pathway that terminates immune and inflammatory responses. Fever, cytopenia, splenomegaly, and/or hemophagocytosis are typical findings of this syndrome. HLH can be induced by genetic disorders (familial) or secondary causes. Familial HLH is rare, while secondary causes in adults include infection, autoimmunity, and malignancy. HLH in adults tends to be confused with or misdiagnosed as sepsis, mainly due to similar clinical manifestations and laboratory findings, which make it difficult to diagnose HLH rapidly and adopt immunosuppressive agents and/or chemotherapy adequately. Treatment of pediatric HLH using HLH-2004 or multi-agent chemotherapy can be applied in adult patients, although the dose and type of drug need to be adjusted. It is highly recommended that allogenic hematopoietic stem cell transplantation should be used in patients who become reactivated or are refractory to the initial treatment as soon as possible to improve survival. Future clinical trials are warranted to determine more suitable treatments for adult patients with HLH. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korea Society of Hematology | - |
dc.relation.isPartOf | BLOOD RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Current status of the diagnosis and treatment of hemophagocytic lymphohistiocytosis in adults | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Yu Ri Kim | - |
dc.contributor.googleauthor | Dae-Young Kim | - |
dc.identifier.doi | 10.5045/br.2021.2020323 | - |
dc.contributor.localId | A00779 | - |
dc.relation.journalcode | J00346 | - |
dc.identifier.eissn | 2288-0011 | - |
dc.identifier.pmid | 33935031 | - |
dc.identifier.url | https://www.bloodresearch.or.kr/journal/view.html?doi=10.5045/br.2021.2020323 | - |
dc.subject.keyword | Hemophagocytic lymphohistiocytosis | - |
dc.subject.keyword | Hemophagocytic syndrome | - |
dc.contributor.alternativeName | Kim, Yu Ri | - |
dc.contributor.affiliatedAuthor | 김유리 | - |
dc.citation.volume | 56 | - |
dc.citation.number | S1 | - |
dc.citation.startPage | S17 | - |
dc.citation.endPage | S25 | - |
dc.identifier.bibliographicCitation | BLOOD RESEARCH, Vol.56(S1) : S17-S25, 2021-04 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.