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Scopolamine promotes neuroinflammation and delirium-like neuropsychiatric disorder in mice

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dc.contributor.author구본녀-
dc.contributor.author김소연-
dc.contributor.author김은정-
dc.contributor.author김소연-
dc.contributor.author김은정-
dc.date.accessioned2021-09-29T00:48:43Z-
dc.date.available2021-09-29T00:48:43Z-
dc.date.issued2021-04-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184047-
dc.description.abstractPostoperative delirium is a common neuropsychiatric syndrome resulting a high postsurgical mortality rate and decline in postdischarge function. Extensive research has been performed on both human and animal delirium-like models due to their clinical significance, focusing on systematic inflammation and consequent neuroinflammation playing a key role in the pathogenesis of postoperative cognitive dysfunctions. Since animal models are widely utilized for pathophysiological study of neuropsychiatric disorders, this study aimed at examining the validity of the scopolamine-induced delirium-like mice model with respect to the neuroinflammatory hypothesis of delirium. Male C57BL/6 mice were treated with intraperitoneal scopolamine (2 mg/kg). Neurobehavioral tests were performed to evaluate the changes in cognitive functions, including learning and memory, and the level of anxiety after surgery or scopolamine treatment. The levels of pro-inflammatory cytokines (IL-1β, IL-18, and TNF-α) and inflammasome components (NLRP3, ASC, and caspase-1) in different brain regions were measured. Gene expression profiles were also examined using whole-genome RNA sequencing analyses to compare gene expression patterns of different mice models. Scopolamine treatment showed significant increase in the level of anxiety and impairments in memory and cognitive function associated with increased level of pro-inflammatory cytokines and NLRP3 inflammasome components. Genetic analysis confirmed the different expression patterns of genes involved in immune response and inflammation and those related with the development of the nervous system in both surgery and scopolamine-induced mice models. The scopolamine-induced delirium-like mice model successfully showed that analogous neuropsychiatric changes coincides with the neuroinflammatory hypothesis for pathogenesis of delirium.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleScopolamine promotes neuroinflammation and delirium-like neuropsychiatric disorder in mice-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology and Pain Medicine (마취통증의학교실)-
dc.contributor.googleauthorSo Yeong Cheon-
dc.contributor.googleauthorBon-Nyeo Koo-
dc.contributor.googleauthorSo Yeon Kim-
dc.contributor.googleauthorEun Hee Kam-
dc.contributor.googleauthorJunhyun Nam-
dc.contributor.googleauthorEun Jung Kim-
dc.identifier.doi10.1038/s41598-021-87790-y-
dc.contributor.localIdA00193-
dc.contributor.localIdA00616-
dc.contributor.localIdA00816-
dc.contributor.localIdA00616-
dc.contributor.localIdA00816-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid33863952-
dc.contributor.alternativeNameKu, Bon Nyo-
dc.contributor.affiliatedAuthor구본녀-
dc.contributor.affiliatedAuthor김소연-
dc.contributor.affiliatedAuthor김은정-
dc.contributor.affiliatedAuthor김소연-
dc.contributor.affiliatedAuthor김은정-
dc.citation.volume11-
dc.citation.number1-
dc.citation.startPage8376-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.11(1) : 8376, 2021-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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