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Common and differential effects of docosahexaenoic acid and eicosapentaenoic acid on helper T-cell responses and associated pathways

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dc.contributor.author강석민-
dc.contributor.author박성하-
dc.contributor.author오재원-
dc.contributor.author이상학-
dc.contributor.author이찬주-
dc.contributor.author박성하-
dc.contributor.author오재원-
dc.contributor.author이상학-
dc.contributor.author이찬주-
dc.date.accessioned2021-09-29T00:46:24Z-
dc.date.available2021-09-29T00:46:24Z-
dc.date.issued2021-05-
dc.identifier.issn1976-6696-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184029-
dc.description.abstractOur understanding of the differential effects between specific omega-3 fatty acids is incomplete. Here, we aimed to evaluate the effects of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on T-helper type 1 (Th1) cell responses and identify the pathways associated with these responses. Naïve CD4+ T cells were co-cultured with bone marrow-derived dendritic cells (DCs) in the presence or absence of palmitate (PA), DHA, or EPA. DHA or EPA treatment lowered the number of differentiated IFN-γ-positive cells and inhibited the secretion of IFN-γ, whereas only DHA increased IL-2 and reduced TNF-α secretion. There was reduced expression of MHC II on DCs after DHA or EPA treatment. In the DC-independent model, DHA and EPA reduced Th1 cell differentiation and lowered the cell number. DHA and EPA markedly inhibited IFN-γ secretion, while only EPA reduced TNF-α secretion. Microarray analysis identified pathways involved in inflammation, immunity, metabolism, and cell proliferation. Moreover, DHA and EPA inhibited Th1 cells through the regulation of diverse pathways and genes, including Igf1 and Cpt1a. Our results showed that DHA and EPA had largely comparable inhibitory effects on Th1 cell differentiation. However, each of the fatty acids also had distinct effects on specific cytokine secretion, particularly according to the presence of DCs.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Society for Biochemistry and Molecular Biology-
dc.relation.isPartOfBMB REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleCommon and differential effects of docosahexaenoic acid and eicosapentaenoic acid on helper T-cell responses and associated pathways-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorJaeho Lee-
dc.contributor.googleauthorYu Ri Choi-
dc.contributor.googleauthorMiso Kim-
dc.contributor.googleauthorJung Mi Park-
dc.contributor.googleauthorMoonjong Kang-
dc.contributor.googleauthorJaewon Oh-
dc.contributor.googleauthorChan Joo Lee-
dc.contributor.googleauthorSungha Park-
dc.contributor.googleauthorSeok-Min Kang-
dc.contributor.googleauthorIchiro Manabe-
dc.contributor.googleauthorSoo-Jin Ann-
dc.contributor.googleauthorSang-Hak Lee-
dc.identifier.doi10.5483/BMBRep.2021.54.5.267-
dc.contributor.localIdA00037-
dc.contributor.localIdA01512-
dc.contributor.localIdA02395-
dc.contributor.localIdA02833-
dc.contributor.localIdA03238-
dc.contributor.localIdA01512-
dc.contributor.localIdA02395-
dc.contributor.localIdA02833-
dc.contributor.localIdA03238-
dc.relation.journalcodeJ00348-
dc.identifier.eissn1976-670X-
dc.identifier.pmid33972011-
dc.contributor.alternativeNameKang, Seok Min-
dc.contributor.affiliatedAuthor강석민-
dc.contributor.affiliatedAuthor박성하-
dc.contributor.affiliatedAuthor오재원-
dc.contributor.affiliatedAuthor이상학-
dc.contributor.affiliatedAuthor이찬주-
dc.contributor.affiliatedAuthor박성하-
dc.contributor.affiliatedAuthor오재원-
dc.contributor.affiliatedAuthor이상학-
dc.contributor.affiliatedAuthor이찬주-
dc.citation.volume54-
dc.citation.number5-
dc.citation.startPage278-
dc.citation.endPage283-
dc.identifier.bibliographicCitationBMB REPORTS, Vol.54(5) : 278-283, 2021-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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