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Chronological analysis of surgical and oncological outcomes after the treatment of perihilar cholangiocarcinoma
DC Field | Value | Language |
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dc.contributor.author | 김경식 | - |
dc.contributor.author | 노승윤 | - |
dc.contributor.author | 최기홍 | - |
dc.contributor.author | 최진섭 | - |
dc.contributor.author | 한대훈 | - |
dc.date.accessioned | 2021-09-29T00:45:35Z | - |
dc.date.available | 2021-09-29T00:45:35Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.issn | 2508-5778 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184022 | - |
dc.description.abstract | Backgrounds/aims: Despite advances in surgical techniques and perioperative supportive care, radical resection of hilar cholangiocarcinoma is the only modality that can achieve long-term survival. We chronologically investigated surgical and oncological outcomes of hilar cholangiocarcinoma and analyzed the factors affecting overall survival. Methods: We retrospectively enrolled 165 patients with hilar cholangiocarcinoma who underwent liver resection with a curative intent. The patients were divided into groups based on the period when the surgery was performed: period I (2005-2011) and period II (2012-2018). The clinicopathological characteristics, perioperative outcomes, and survival outcomes were analyzed. Results: The patients' age, serum CA19-9 levels, and serum bilirubin levels at diagnosis were significantly higher in the period I group. There were no differences in pathological characteristics such as tumor stage, histopathologic status, and resection status. However, perioperative outcomes, such as estimated blood loss (1528.8 vs. 1034.1 mL, p=0.020) and postoperative severe complication rate (51.3% vs. 26.4%, p=0.022), were significantly lower in the period II group. Regression analysis demonstrated that period I (hazard ratio [HR]=1.591; 95% confidence interval [CI]=1.049-2.414; p=0.029), preoperative serum bilirubin at diagnosis (HR=1.585; 95% CI=1.058-2.374; p=0.026), and tumor stage (III, IV) (HR=1.671; 95% CI: 1.133-2.464; p=0.010) were significantly associated with poor prognosis. The 5-year survival rate was better in the period II patients than in the period I patients (35.1% vs. 21.0%, p=0.0071). Conclusions: The surgical and oncological outcomes were better in period II. Preoperative serum bilirubin and advanced tumor stage were associated with poor prognosis in patients with hilar cholangiocarcinoma. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Annals of Hepato-biliary-pancreatic Surgery | - |
dc.publisher | Annals of Hepato-biliary-pancreatic Surgery | - |
dc.relation.isPartOf | Annals of Hepato-biliary-pancreatic Surgery | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Chronological analysis of surgical and oncological outcomes after the treatment of perihilar cholangiocarcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학교실) | - |
dc.contributor.googleauthor | Sung Ho Lee | - |
dc.contributor.googleauthor | Gi Hong Choi | - |
dc.contributor.googleauthor | Dai Hoon Han | - |
dc.contributor.googleauthor | Kyung Sik Kim | - |
dc.contributor.googleauthor | Jin Sub Choi | - |
dc.contributor.googleauthor | Seoung Yoon Rho | - |
dc.identifier.doi | 10.14701/ahbps.2021.25.1.62 | - |
dc.contributor.localId | A00299 | - |
dc.contributor.localId | A05469 | - |
dc.contributor.localId | A04046 | - |
dc.contributor.localId | A04199 | - |
dc.contributor.localId | A04273 | - |
dc.relation.journalcode | J03067 | - |
dc.identifier.eissn | 2508-5859 | - |
dc.identifier.pmid | 33649256 | - |
dc.subject.keyword | Chronological analysis | - |
dc.subject.keyword | Hilar cholangiocarcinoma | - |
dc.subject.keyword | Klatskin tumor | - |
dc.subject.keyword | Oncological outcome | - |
dc.subject.keyword | Surgical outcome | - |
dc.subject.keyword | Survival | - |
dc.contributor.alternativeName | Kim, Kyung Sik | - |
dc.contributor.affiliatedAuthor | 김경식 | - |
dc.contributor.affiliatedAuthor | 노승윤 | - |
dc.contributor.affiliatedAuthor | 최기홍 | - |
dc.contributor.affiliatedAuthor | 최진섭 | - |
dc.contributor.affiliatedAuthor | 한대훈 | - |
dc.citation.volume | 25 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 62 | - |
dc.citation.endPage | 70 | - |
dc.identifier.bibliographicCitation | Annals of Hepato-biliary-pancreatic Surgery, Vol.25(1) : 62-70, 2021-02 | - |
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