Cited 18 times in
The immunomodulatory effect of ketamine in colorectal cancer surgery: a randomized-controlled trial
DC Field | Value | Language |
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dc.contributor.author | 곽영란 | - |
dc.contributor.author | 김나영 | - |
dc.contributor.author | 심재광 | - |
dc.contributor.author | 조진선 | - |
dc.contributor.author | 전지혜 | - |
dc.date.accessioned | 2021-09-29T00:45:27Z | - |
dc.date.available | 2021-09-29T00:45:27Z | - |
dc.date.issued | 2021-05 | - |
dc.identifier.issn | 0832-610X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184021 | - |
dc.description.abstract | Purpose: Ketamine's inhibitory action on the N-methyl-D-aspartate receptor and anti-inflammatory effects may provide beneficial immunomodulation in cancer surgery. We investigated the effect of subanesthetic-dose ketamine as an adjunct to desflurane anesthesia on natural killer (NK) cell activity and inflammation in patients undergoing colorectal cancer surgery. Methods: A total of 100 patients were randomly assigned to a control or ketamine group. The ketamine group received a bolus of 0.25 mg·kg-1 ketamine five minutes before the start of surgery, followed by an infusion 0.05 mg·kg-1·hr-1 until the end of surgery; the control group received a similar amount of normal saline. We measured NK cell activity and proinflammatory cytokines (interleukin-6 [IL-6] and tumour necrosis factor-α [TNF-α]) before surgery and one, 24, and 48 hr after surgery. C-reactive protein (CRP) was measured before surgery and one, three, and five days after surgery. Carcinoembryonic antigen and cancer recurrence/metastasis were assessed two years after surgery. Results: The NK cell activity was significantly decreased after surgery in both groups, but the change was not different between groups in the linear mixed model analysis (P = 0.47). Changes in IL-6, TNF-α, CRP, and carcinoembryonic antigen levels were not different between groups (P = 0.27, 0.69, 0.99, and 0.97, respectively). Cancer recurrence within 2 years after surgery was similar between groups (10% vs 8%, P = 0.62). Conclusions: Intraoperative low-dose ketamine administration did not convey any favourable impacts on overall postoperative NK cell activity, inflammatory responses, and prognosis in colorectal cancer surgery patients. Trial registration: www.clinicaltrial.gov (NCT03273231); registered 6 September 2017. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer New York | - |
dc.relation.isPartOf | CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Colorectal Neoplasms* / surgery | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunomodulation | - |
dc.subject.MESH | Interleukin-6 | - |
dc.subject.MESH | Ketamine* | - |
dc.subject.MESH | Tumor Necrosis Factor-alpha | - |
dc.title | The immunomodulatory effect of ketamine in colorectal cancer surgery: a randomized-controlled trial | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) | - |
dc.contributor.googleauthor | Jin Sun Cho | - |
dc.contributor.googleauthor | Na Young Kim | - |
dc.contributor.googleauthor | Jae-Kwang Shim | - |
dc.contributor.googleauthor | Ji Hae Jun | - |
dc.contributor.googleauthor | Sugeun Lee | - |
dc.contributor.googleauthor | Young-Lan Kwak | - |
dc.identifier.doi | 10.1007/s12630-021-01925-3 | - |
dc.contributor.localId | A00172 | - |
dc.contributor.localId | A00348 | - |
dc.contributor.localId | A02205 | - |
dc.contributor.localId | A03914 | - |
dc.relation.journalcode | J00426 | - |
dc.identifier.eissn | 1496-8975 | - |
dc.identifier.pmid | 33532995 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs12630-021-01925-3 | - |
dc.subject.keyword | cancer surgery | - |
dc.subject.keyword | colorectal cancer | - |
dc.subject.keyword | immunity | - |
dc.subject.keyword | inflammation | - |
dc.subject.keyword | ketamine | - |
dc.subject.keyword | natural killer cell | - |
dc.contributor.alternativeName | Kwak, Young Lan | - |
dc.contributor.affiliatedAuthor | 곽영란 | - |
dc.contributor.affiliatedAuthor | 김나영 | - |
dc.contributor.affiliatedAuthor | 심재광 | - |
dc.contributor.affiliatedAuthor | 조진선 | - |
dc.citation.volume | 68 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 683 | - |
dc.citation.endPage | 692 | - |
dc.identifier.bibliographicCitation | CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE, Vol.68(5) : 683-692, 2021-05 | - |
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