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Characteristics of community-acquired respiratory viruses infections except seasonal influenza in transplant recipients and non-transplant critically ill patients

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dc.contributor.author김명수-
dc.contributor.author김순일-
dc.contributor.author김유선-
dc.contributor.author김진석-
dc.contributor.author민유홍-
dc.contributor.author송영구-
dc.contributor.author이경화-
dc.contributor.author정준원-
dc.contributor.author조용근-
dc.contributor.author최진섭-
dc.contributor.author한상훈-
dc.contributor.author김순일-
dc.contributor.author김유선-
dc.contributor.author김진석-
dc.contributor.author민유홍-
dc.contributor.author송영구-
dc.contributor.author이경화-
dc.contributor.author정준원-
dc.contributor.author조용근-
dc.contributor.author최진섭-
dc.contributor.author한상훈-
dc.date.accessioned2021-09-29T00:44:42Z-
dc.date.available2021-09-29T00:44:42Z-
dc.date.issued2021-04-
dc.identifier.issn1684-1182-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184015-
dc.description.abstractBackground/purpose: Transplant recipients are vulnerable to life-threatening community-acquired respiratory viruses (CA-RVs) infection (CA-RVI). Even if non-transplant critically ill patients in intensive care unit (ICU) have serious CA-RVI, comparison between these groups remains unclear. We aimed to evaluate clinical characteristics and mortality of CA-RVI except seasonal influenza A/B in transplant recipients and non-transplant critically ill patients in ICU. Methods: We collected 37,777 CA-RVs multiplex real-time reverse transcription-polymerase chain reaction test results of individuals aged ≥18 years from November 2012 to November 2017. The CA-RVs tests included adenovirus, coronavirus 229E/NL63/OC43, human bocavirus, human metapneumovirus, parainfluenza virus 1/2/3, rhinovirus, and respiratory syncytial virus A/B. Results: We found 286 CA-RVI cases, including 85 solid organ transplantation recipients (G1), 61 hematopoietic stem cell transplantation recipients (G2), and 140 non-transplant critically ill patients in ICU (G3), excluding those with repeated isolation within 30 days. Adenovirus positive rate and infection cases were most prominent in G2 (p < 0.001). The median time interval between transplantation and CA-RVI was 30 and 20 months in G1 and G2, respectively. All-cause in-hospital mortality was significantly higher in G3 than in G1 or G2 (51.4% vs. 28.2% or 39.3%, p = 0.002, respectively). The mechanical ventilation (MV) was the independent risk factor associated with all-cause in-hospital mortality in all three groups (hazard ratio, 3.37, 95% confidence interval, 2.04-5.56, p < 0.001). Conclusions: This study highlights the importance of CA-RVs diagnosis in transplant recipients even in long-term posttransplant period, and in non-transplant critically ill patients in ICU with MV.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish, Chinese-
dc.publisherElsevier for the Taiwan Society of Microbiology-
dc.relation.isPartOfJOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHCohort Studies-
dc.subject.MESHCommunity-Acquired Infections / etiology*-
dc.subject.MESHCommunity-Acquired Infections / mortality-
dc.subject.MESHCommunity-Acquired Infections / virology-
dc.subject.MESHCritical Illness-
dc.subject.MESHDisease Susceptibility-
dc.subject.MESHFemale-
dc.subject.MESHHematopoietic Stem Cell Transplantation / adverse effects-
dc.subject.MESHHumans-
dc.subject.MESHImmunocompromised Host-
dc.subject.MESHImmunosuppression / adverse effects-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOrgan Transplantation / adverse effects-
dc.subject.MESHRepublic of Korea / epidemiology-
dc.subject.MESHRespiratory Tract Infections / etiology*-
dc.subject.MESHRespiratory Tract Infections / mortality-
dc.subject.MESHRespiratory Tract Infections / virology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHTransplant Recipients*-
dc.titleCharacteristics of community-acquired respiratory viruses infections except seasonal influenza in transplant recipients and non-transplant critically ill patients-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Surgery (외과학교실)-
dc.contributor.googleauthorKyoung Hwa Lee-
dc.contributor.googleauthorSeul Gi Yoo-
dc.contributor.googleauthorYonggeun Cho-
dc.contributor.googleauthorDa Eun Kwon-
dc.contributor.googleauthorYeonju La-
dc.contributor.googleauthorSang Hoon Han-
dc.contributor.googleauthorMyoung Soo Kim-
dc.contributor.googleauthorJin Sub Choi-
dc.contributor.googleauthorSoon Il Kim-
dc.contributor.googleauthorYu Seun Kim-
dc.contributor.googleauthorYoo Hong Min-
dc.contributor.googleauthorJune-Won Cheong-
dc.contributor.googleauthorJin Seok Kim-
dc.contributor.googleauthorYong Goo Song-
dc.identifier.doi10.1016/j.jmii.2019.05.007-
dc.contributor.localIdA00424-
dc.contributor.localIdA00649-
dc.contributor.localIdA00785-
dc.contributor.localIdA01017-
dc.contributor.localIdA01407-
dc.contributor.localIdA02037-
dc.contributor.localIdA04620-
dc.contributor.localIdA03729-
dc.contributor.localIdA03864-
dc.contributor.localIdA04199-
dc.contributor.localIdA04286-
dc.contributor.localIdA00649-
dc.contributor.localIdA00785-
dc.contributor.localIdA01017-
dc.contributor.localIdA01407-
dc.contributor.localIdA02037-
dc.contributor.localIdA04620-
dc.contributor.localIdA03729-
dc.contributor.localIdA03864-
dc.contributor.localIdA04199-
dc.contributor.localIdA04286-
dc.relation.journalcodeJ01595-
dc.identifier.eissn1995-9133-
dc.identifier.pmid31262511-
dc.subject.keywordCommunity-acquired respiratory viruses-
dc.subject.keywordCritically ill patients-
dc.subject.keywordHematopoietic stem cell transplantation-
dc.subject.keywordMortality-
dc.subject.keywordSolid organ transplantation-
dc.contributor.alternativeNameKim, Myoung Soo-
dc.contributor.affiliatedAuthor김명수-
dc.contributor.affiliatedAuthor김순일-
dc.contributor.affiliatedAuthor김유선-
dc.contributor.affiliatedAuthor김진석-
dc.contributor.affiliatedAuthor민유홍-
dc.contributor.affiliatedAuthor송영구-
dc.contributor.affiliatedAuthor이경화-
dc.contributor.affiliatedAuthor정준원-
dc.contributor.affiliatedAuthor조용근-
dc.contributor.affiliatedAuthor최진섭-
dc.contributor.affiliatedAuthor한상훈-
dc.contributor.affiliatedAuthor김순일-
dc.contributor.affiliatedAuthor김유선-
dc.contributor.affiliatedAuthor김진석-
dc.contributor.affiliatedAuthor민유홍-
dc.contributor.affiliatedAuthor송영구-
dc.contributor.affiliatedAuthor이경화-
dc.contributor.affiliatedAuthor정준원-
dc.contributor.affiliatedAuthor조용근-
dc.contributor.affiliatedAuthor최진섭-
dc.contributor.affiliatedAuthor한상훈-
dc.citation.volume54-
dc.citation.number2-
dc.citation.startPage253-
dc.citation.endPage260-
dc.identifier.bibliographicCitationJOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION, Vol.54(2) : 253-260, 2021-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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