25 77

Cited 0 times in

Characteristics of community-acquired respiratory viruses infections except seasonal influenza in transplant recipients and non-transplant critically ill patients

Authors
 Kyoung Hwa Lee  ;  Seul Gi Yoo  ;  Yonggeun Cho  ;  Da Eun Kwon  ;  Yeonju La  ;  Sang Hoon Han  ;  Myoung Soo Kim  ;  Jin Sub Choi  ;  Soon Il Kim  ;  Yu Seun Kim  ;  Yoo Hong Min  ;  June-Won Cheong  ;  Jin Seok Kim  ;  Yong Goo Song 
Citation
 JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION, Vol.54(2) : 253-260, 2021-04 
Journal Title
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
ISSN
 1684-1182 
Issue Date
2021-04
MeSH
Adult ; Aged ; Cohort Studies ; Community-Acquired Infections / etiology* ; Community-Acquired Infections / mortality ; Community-Acquired Infections / virology ; Critical Illness ; Disease Susceptibility ; Female ; Hematopoietic Stem Cell Transplantation / adverse effects ; Humans ; Immunocompromised Host ; Immunosuppression / adverse effects ; Male ; Middle Aged ; Organ Transplantation / adverse effects ; Republic of Korea / epidemiology ; Respiratory Tract Infections / etiology* ; Respiratory Tract Infections / mortality ; Respiratory Tract Infections / virology ; Retrospective Studies ; Risk Factors ; Transplant Recipients*
Keywords
Community-acquired respiratory viruses ; Critically ill patients ; Hematopoietic stem cell transplantation ; Mortality ; Solid organ transplantation
Abstract
Background/purpose: Transplant recipients are vulnerable to life-threatening community-acquired respiratory viruses (CA-RVs) infection (CA-RVI). Even if non-transplant critically ill patients in intensive care unit (ICU) have serious CA-RVI, comparison between these groups remains unclear. We aimed to evaluate clinical characteristics and mortality of CA-RVI except seasonal influenza A/B in transplant recipients and non-transplant critically ill patients in ICU.

Methods: We collected 37,777 CA-RVs multiplex real-time reverse transcription-polymerase chain reaction test results of individuals aged ≥18 years from November 2012 to November 2017. The CA-RVs tests included adenovirus, coronavirus 229E/NL63/OC43, human bocavirus, human metapneumovirus, parainfluenza virus 1/2/3, rhinovirus, and respiratory syncytial virus A/B.

Results: We found 286 CA-RVI cases, including 85 solid organ transplantation recipients (G1), 61 hematopoietic stem cell transplantation recipients (G2), and 140 non-transplant critically ill patients in ICU (G3), excluding those with repeated isolation within 30 days. Adenovirus positive rate and infection cases were most prominent in G2 (p < 0.001). The median time interval between transplantation and CA-RVI was 30 and 20 months in G1 and G2, respectively. All-cause in-hospital mortality was significantly higher in G3 than in G1 or G2 (51.4% vs. 28.2% or 39.3%, p = 0.002, respectively). The mechanical ventilation (MV) was the independent risk factor associated with all-cause in-hospital mortality in all three groups (hazard ratio, 3.37, 95% confidence interval, 2.04-5.56, p < 0.001).

Conclusions: This study highlights the importance of CA-RVs diagnosis in transplant recipients even in long-term posttransplant period, and in non-transplant critically ill patients in ICU with MV.
Files in This Item:
T202101883.pdf Download
DOI
10.1016/j.jmii.2019.05.007
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Soo(김명수) ORCID logo https://orcid.org/0000-0002-8975-8381
Kim, Soon Il(김순일) ORCID logo https://orcid.org/0000-0002-0783-7538
Kim, Yu Seun(김유선) ORCID logo https://orcid.org/0000-0002-5105-1567
Kim, Jin Seok(김진석) ORCID logo https://orcid.org/0000-0001-8986-8436
Min, Yoo Hong(민유홍) ORCID logo https://orcid.org/0000-0001-8542-9583
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Lee, Kyoung Hwa(이경화) ORCID logo https://orcid.org/0000-0003-0033-1398
Cheong, June-Won(정준원) ORCID logo https://orcid.org/0000-0002-1744-0921
Cho, Yonggeun(조용근) ORCID logo https://orcid.org/0000-0003-1946-4318
Choi, Jin Sub(최진섭)
Han, Sang Hoon(한상훈) ORCID logo https://orcid.org/0000-0002-4278-5198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184015
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links