Cited 10 times in
Marliolide Derivative Induces Melanosome Degradation via Nrf2/p62-Mediated Autophagy
DC Field | Value | Language |
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dc.contributor.author | 오상호 | - |
dc.date.accessioned | 2021-09-29T00:44:18Z | - |
dc.date.available | 2021-09-29T00:44:18Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184010 | - |
dc.description.abstract | Nuclear factor erythroid 2-related factor 2 (Nrf2), which is linked to autophagy regulation and melanogenesis regulation, is activated by marliolide. In this study, we investigated the effect of a marliolide derivative on melanosome degradation through the autophagy pathway. The effect of the marliolide derivative on melanosome degradation was investigated in α-melanocyte stimulating hormone (α-MSH)-treated melanocytes, melanosome-incorporated keratinocyte, and ultraviolet (UV)B-exposed HRM-2 mice (melanin-possessing hairless mice). The marliolide derivative, 5-methyl-3-tetradecylidene-dihydro-furan-2-one (DMF02), decreased melanin pigmentation by melanosome degradation in α-MSH-treated melanocytes and melanosome-incorporated keratinocytes, evidenced by premelanosome protein (PMEL) expression, but did not affect melanogenesis-associated proteins. The UVB-induced hyperpigmentation in HRM-2 mice was also reduced by a topical application of DMF02. DMF02 activated Nrf2 and induced autophagy in vivo, evidenced by decreased PMEL in microtubule-associated proteins 1A/1B light chain 3B (LC3)-II-expressed areas. DMF02 also induced melanosome degradation via autophagy in vitro, and DMF02-induced melanosome degradation was recovered by chloroquine (CQ), which is a lysosomal inhibitor. In addition, Nrf2 silencing by siRNA attenuated the DMF02-induced melanosome degradation via the suppression of p62. DMF02 induced melanosome degradation in melanocytes and keratinocytes by regulating autophagy via Nrf2-p62 activation. Therefore, Nrf2 activator could be a promising therapeutic agent for reducing hyperpigmentation. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.publisher | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Autophagy* / drug effects | - |
dc.subject.MESH | Autophagy* / radiation effects | - |
dc.subject.MESH | Gene Knockdown Techniques | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Keratinocytes / drug effects | - |
dc.subject.MESH | Keratinocytes / metabolism | - |
dc.subject.MESH | Keratinocytes / radiation effects | - |
dc.subject.MESH | Lactones / chemistry | - |
dc.subject.MESH | Lactones / pharmacology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Melanins / metabolism | - |
dc.subject.MESH | Melanocytes / drug effects | - |
dc.subject.MESH | Melanocytes / metabolism | - |
dc.subject.MESH | Melanocytes / radiation effects | - |
dc.subject.MESH | Melanoma, Experimental / pathology | - |
dc.subject.MESH | Melanosomes / metabolism* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | NF-E2-Related Factor 2 / metabolism* | - |
dc.subject.MESH | Sequestosome-1 Protein / metabolism* | - |
dc.subject.MESH | Skin Pigmentation / drug effects | - |
dc.subject.MESH | Skin Pigmentation / radiation effects | - |
dc.subject.MESH | Ultraviolet Rays | - |
dc.title | Marliolide Derivative Induces Melanosome Degradation via Nrf2/p62-Mediated Autophagy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Dermatology (피부과학교실) | - |
dc.contributor.googleauthor | Cheong-Yong Yun | - |
dc.contributor.googleauthor | Nahyun Choi | - |
dc.contributor.googleauthor | Jae Un Lee | - |
dc.contributor.googleauthor | Eun Jung Lee | - |
dc.contributor.googleauthor | Ji Young Kim | - |
dc.contributor.googleauthor | Won Jun Choi | - |
dc.contributor.googleauthor | Sang Ho Oh | - |
dc.contributor.googleauthor | Jong-Hyuk Sung | - |
dc.identifier.doi | 10.3390/ijms22083995 | - |
dc.contributor.localId | A02370 | - |
dc.relation.journalcode | J01133 | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.pmid | 33924406 | - |
dc.subject.keyword | Nrf2 | - |
dc.subject.keyword | autophagy | - |
dc.subject.keyword | melanosome degradation | - |
dc.subject.keyword | p62 | - |
dc.contributor.alternativeName | Oh, Sang Ho | - |
dc.contributor.affiliatedAuthor | 오상호 | - |
dc.citation.volume | 22 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 3995 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.22(8) : 3995, 2021-04 | - |
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