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Overexpression of PVR and PD-L1 and its association with prognosis in surgically resected squamous cell lung carcinoma
DC Field | Value | Language |
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dc.contributor.author | 김혜련 | - |
dc.contributor.author | 박성용 | - |
dc.contributor.author | 심효섭 | - |
dc.contributor.author | 홍민희 | - |
dc.date.accessioned | 2021-09-29T00:40:09Z | - |
dc.date.available | 2021-09-29T00:40:09Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183978 | - |
dc.description.abstract | Targeting T-Cell Immunoreceptor with Ig and ITIM domain-poliovirus receptor (PVR) pathway is a potential therapeutic strategy in lung cancer. We analyzed the expression of PVR and programmed death ligand-1 (PD-L1) in surgically resected squamous cell lung carcinoma (SQCC) and determined its prognostic significance. We collected archival surgical specimens and data of 259 patients with SQCC at Yonsei Cancer Center (1998-2020). Analysis of variance was used to analyze the correlations between PVR and PD-L1 expression and patient characteristics. Kaplan-Meier curves were used to estimate recurrence-free survival (RFS) and overall survival (OS). Most patients were male (93%); the majority were diagnosed with stage 1 (47%), followed by stage 2 (29%) and stage 3 (21%). Overexpression of PVR resulted in a significantly shorter median RFS and OS (P = 0.01). PD-L1 expression was not significant in terms of prognosis. Patients were subdivided into four groups based on low and high PVR and PD-L1 expression. Those expressing high levels of PVR and PD-L1 had the shortest RFS (P = 0.03). PVR overexpression is associated with a poor prognosis in surgically resected SQCC. Inhibition of PVR as well as PD-L1 may help overcome the lack of response to immune checkpoint monotherapy. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Overexpression of PVR and PD-L1 and its association with prognosis in surgically resected squamous cell lung carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jii Bum Lee | - |
dc.contributor.googleauthor | Min Hee Hong | - |
dc.contributor.googleauthor | Seong Yong Park | - |
dc.contributor.googleauthor | Sehyun Chae | - |
dc.contributor.googleauthor | Daehee Hwang | - |
dc.contributor.googleauthor | Sang-Jun Ha | - |
dc.contributor.googleauthor | Hyo Sup Shim | - |
dc.contributor.googleauthor | Hye Ryun Kim | - |
dc.identifier.doi | 10.1038/s41598-021-87624-x | - |
dc.contributor.localId | A01166 | - |
dc.contributor.localId | A01508 | - |
dc.contributor.localId | A02219 | - |
dc.contributor.localId | A04393 | - |
dc.relation.journalcode | J02646 | - |
dc.identifier.eissn | 2045-2322 | - |
dc.identifier.pmid | 33879814 | - |
dc.contributor.alternativeName | Kim, Hye Ryun | - |
dc.contributor.affiliatedAuthor | 김혜련 | - |
dc.contributor.affiliatedAuthor | 박성용 | - |
dc.contributor.affiliatedAuthor | 심효섭 | - |
dc.contributor.affiliatedAuthor | 홍민희 | - |
dc.citation.volume | 11 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 8551 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, Vol.11(1) : 8551, 2021-04 | - |
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