Cited 73 times in
Clinical Insights Into Novel Immune Checkpoint Inhibitors
DC Field | Value | Language |
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dc.contributor.author | 김혜련 | - |
dc.date.accessioned | 2021-09-29T00:40:01Z | - |
dc.date.available | 2021-09-29T00:40:01Z | - |
dc.date.issued | 2021-05 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183976 | - |
dc.description.abstract | The success of immune checkpoint inhibitors (ICIs), notably anti-cytotoxic T lymphocyte associated antigen-4 (CTLA-4) as well as inhibitors of CTLA-4, programmed death 1 (PD-1), and programmed death ligand-1 (PD-L1), has revolutionized treatment options for solid tumors. However, the lack of response to treatment, in terms of de novo or acquired resistance, and immune related adverse events (IRAE) remain as hurdles. One mechanisms to overcome the limitations of ICIs is to target other immune checkpoints associated with tumor microenvironment. Immune checkpoints such as lymphocyte activation gene-3 (LAG-3), T cell immunoglobulin and ITIM domain (TIGIT), T cell immunoglobulin and mucin-domain containing-3 (TIM-3), V-domain immunoglobulin suppressor of T cell activation (VISTA), B7 homolog 3 protein (B7-H3), inducible T cell costimulatory (ICOS), and B and T lymphocyte attenuator (BTLA) are feasible and promising options for treating solid tumors, and clinical trials are currently under active investigation. This review aims to summarize the clinical aspects of the immune checkpoints and introduce novel agents targeting these checkpoints. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Frontiers Media | - |
dc.relation.isPartOf | FRONTIERS IN PHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Clinical Insights Into Novel Immune Checkpoint Inhibitors | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Jii Bum Lee | - |
dc.contributor.googleauthor | Sang-Jun Ha | - |
dc.contributor.googleauthor | Hye Ryun Kim | - |
dc.identifier.doi | 10.3389/fphar.2021.681320 | - |
dc.contributor.localId | A01166 | - |
dc.relation.journalcode | J03340 | - |
dc.identifier.eissn | 1663-9812 | - |
dc.identifier.pmid | 34025438 | - |
dc.subject.keyword | B7-H3 | - |
dc.subject.keyword | BTLA | - |
dc.subject.keyword | ICOS | - |
dc.subject.keyword | LAG-3 | - |
dc.subject.keyword | TIGIT | - |
dc.subject.keyword | TIM-3 | - |
dc.subject.keyword | VISTA | - |
dc.subject.keyword | immune checkpoint | - |
dc.contributor.alternativeName | Kim, Hye Ryun | - |
dc.contributor.affiliatedAuthor | 김혜련 | - |
dc.citation.volume | 12 | - |
dc.citation.startPage | 681320 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN PHARMACOLOGY, Vol.12 : 681320, 2021-05 | - |
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