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Structural connectivity networks in Alzheimer's disease and Lewy body disease

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dc.contributor.author백경원-
dc.contributor.author손영호-
dc.contributor.author예병석-
dc.contributor.author이양현-
dc.contributor.author이필휴-
dc.contributor.author정석종-
dc.contributor.author유한수-
dc.date.accessioned2021-09-29T00:39:50Z-
dc.date.available2021-09-29T00:39:50Z-
dc.date.issued2021-05-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/183975-
dc.description.abstractObjective: We evaluated disruption of the white matter (WM) network related with Alzheimer's disease (AD) and Lewy body disease (LBD), which includes Parkinson's disease and dementia with Lewy bodies. Methods: We consecutively recruited 37 controls and 77 patients with AD-related cognitive impairment (ADCI) and/or LBD-related cognitive impairment (LBCI). Diagnoses of ADCI and LBCI were supported by amyloid PET and dopamine transporter PET, respectively. There were 22 patients with ADCI, 19 patients with LBCI, and 36 patients with mixed ADCI/LBCI. We investigated the relationship between ADCI, LBCI, graph theory-based network measures on diffusion tensor images, and cognitive dysfunction using general linear models after controlling for age, sex, education, deep WM hyperintensities (WMH), periventricular WMH, and intracranial volume. Results: LBCI, especially mixed with ADCI, was associated with increased normalized path length and decreased normalized global efficiency. LBCI was related to the decreased nodal degree of left caudate, which was further associated with broad cognitive dysfunction. Decreased left caudate nodal degree was associated with decreased fractional anisotropy (FA) in the brain regions vulnerable to LBD. Compared with the control group, the LBCI group had an increased betweenness centrality in the occipital nodes, which was associated with decreased FA in the WM adjacent to the striatum and visuospatial dysfunction. Conclusion: Concomitant ADCI and LBCI are associated with the accentuation of LBCI-related WM network disruption centered in the left caudate nucleus. The increase of occipital betweenness centrality could be a characteristic biologic change associated with visuospatial dysfunction in LBCI.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherJohn Wiley & Sons-
dc.relation.isPartOfBRAIN AND BEHAVIOR-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAlzheimer Disease* / diagnostic imaging-
dc.subject.MESHBrain / diagnostic imaging-
dc.subject.MESHCognitive Dysfunction* / diagnostic imaging-
dc.subject.MESHCognitive Dysfunction* / etiology-
dc.subject.MESHHumans-
dc.subject.MESHLewy Body Disease* / diagnostic imaging-
dc.subject.MESHWhite Matter* / diagnostic imaging-
dc.titleStructural connectivity networks in Alzheimer's disease and Lewy body disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorKyoungwon Baik-
dc.contributor.googleauthorJin-Ju Yang-
dc.contributor.googleauthorJin Ho Jung-
dc.contributor.googleauthorYang Hyun Lee-
dc.contributor.googleauthorSeok Jong Chung-
dc.contributor.googleauthorHan Soo Yoo-
dc.contributor.googleauthorYoung H Sohn-
dc.contributor.googleauthorPhil Hyu Lee-
dc.contributor.googleauthorJong-Min Lee-
dc.contributor.googleauthorByoung Seok Ye-
dc.identifier.doi10.1002/brb3.2112-
dc.contributor.localIdA05133-
dc.contributor.localIdA01982-
dc.contributor.localIdA04603-
dc.contributor.localIdA05714-
dc.contributor.localIdA03270-
dc.contributor.localIdA04666-
dc.relation.journalcodeJ02977-
dc.identifier.eissn2162-3279-
dc.identifier.pmid33792194-
dc.subject.keywordalzheimer's disease-
dc.subject.keywordgraph analysis-
dc.subject.keywordlewy body disease-
dc.subject.keywordstructural connectivity-
dc.contributor.alternativeNameBaik, Kyoungwon-
dc.contributor.affiliatedAuthor백경원-
dc.contributor.affiliatedAuthor손영호-
dc.contributor.affiliatedAuthor예병석-
dc.contributor.affiliatedAuthor이양현-
dc.contributor.affiliatedAuthor이필휴-
dc.contributor.affiliatedAuthor정석종-
dc.citation.volume11-
dc.citation.number5-
dc.citation.startPagee02112-
dc.identifier.bibliographicCitationBRAIN AND BEHAVIOR, Vol.11(5) : e02112, 2021-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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