101 190

Cited 0 times in

Association between follistatin-related protein 1 and the functional status of patients with anti-neutrophil cytoplasmic antibody-associated vasculitis

DC Field Value Language
dc.contributor.author박용범-
dc.contributor.author송정식-
dc.contributor.author안성수-
dc.contributor.author이상원-
dc.contributor.author표정윤-
dc.date.accessioned2021-09-29T00:38:11Z-
dc.date.available2021-09-29T00:38:11Z-
dc.date.issued2021-04-
dc.identifier.issn0366-6999-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/183966-
dc.description.abstractBackground: Follistatin-like 1 (FSTL1) plays both pro-inflammatory and anti-inflammatory roles in the inflammatory processes. We investigated whether serum FSTL1 could predict the current anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV)-specific indices. Methods: We randomly selected 74 patients with AAV from a prospective and observational cohort of Korean patients with AAV. Clinical and laboratory data and AAV-specific indices were recorded. FSTL1 concentration was determined using the stored sera. The lowest tertile of the short-form 36-item health survey (SF-36) was defined as the current low SF-36. The cutoffs of serum FSTL1 for the current low SF-36 physical component summary (PCS) and SF-36 mental component summary (MCS) were extrapolated by the receiver operator characteristic curve. Results: The median age was 62.5 years (55.4% were women). Serum FSTL1 was significantly correlated with SF-36 PCS (r = - 0.374), SF-36 MCS (r = -0.377), and C-reactive protein (CRP) (r = 0.307), but not with Birmingham vasculitis activity score (BVAS). In the multivariable linear regression analyses, BVAS, CRP, and serum FSTL1 were independently associated with the current SF-36 PCS (β = -0.255, β = -0.430, and β = -0.266, respectively) and the current SF-36 MCS (β = -0.234, β =-0.229, and β = -0.296, respectively). Patients with serum FSTL1 ≥779.8 pg/mL and those with serum FSTL1 ≥841.6 pg/mL exhibited a significantly higher risk of having the current low SF-36 PCS and SF-36 MCS than those without (relative risk 7.583 and 6.200, respectively). Conclusion: Serum FSTL1 could predict the current functional status in AAV patients.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish, Chinese-
dc.publisherWolters Kluwer-Medknow-
dc.relation.isPartOfCHINESE MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis*-
dc.subject.MESHFemale-
dc.subject.MESHFollistatin-
dc.subject.MESHFollistatin-Related Proteins*-
dc.subject.MESHFunctional Status-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProspective Studies-
dc.subject.MESHSeverity of Illness Index-
dc.titleAssociation between follistatin-related protein 1 and the functional status of patients with anti-neutrophil cytoplasmic antibody-associated vasculitis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorTaejun Yoon-
dc.contributor.googleauthorSung Soo Ahn-
dc.contributor.googleauthorJung Yoon Pyo-
dc.contributor.googleauthorJason Jungsik Song-
dc.contributor.googleauthorYong-Beom Park-
dc.contributor.googleauthorSang-Won Lee-
dc.identifier.doi10.1097/CM9.0000000000001454-
dc.contributor.localIdA01579-
dc.contributor.localIdA02057-
dc.contributor.localIdA02233-
dc.contributor.localIdA02824-
dc.contributor.localIdA04244-
dc.relation.journalcodeJ00527-
dc.identifier.pmid34018995-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.affiliatedAuthor박용범-
dc.contributor.affiliatedAuthor송정식-
dc.contributor.affiliatedAuthor안성수-
dc.contributor.affiliatedAuthor이상원-
dc.contributor.affiliatedAuthor표정윤-
dc.citation.volume134-
dc.citation.number10-
dc.citation.startPage1168-
dc.citation.endPage1174-
dc.identifier.bibliographicCitationCHINESE MEDICAL JOURNAL, Vol.134(10) : 1168-1174, 2021-04-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.